DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp8 and si:ch211-241j12.3

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_017207998.2	Gene:	si:ch211-241j12.3 / 566552	ZFINID:	ZDB-GENE-040724-72	Length:	1245	Species:	Danio rerio

Alignment Length:	695	Identity:	116/695 - (16%)
Similarity:	214/695 - (30%)	Gaps:	254/695 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PQAQPLEAPKI---------------IVIHPGSQHLRIGR---------AADLNPL------TLL 59
            |..:||.:...               ::|.|.:.|..:|:         |.||..|      :.|
Zfish   680 PHGEPLSSSSASPFAVSPYLPDTSTSVLIRPEAAHPLVGKSSTWEPTDTAVDLEELQVCGVPSAL 744

  Fly    60 HAVAYRRR--PG------ASDRP-----HHDPLLPPLDNVNSNSGLMVEF--------------- 96
            .:...|..  ||      |..|.     .|||....|.:..:::|.:.|.
Zfish   745 ESSDVRSEFDPGGVPIAAAPQRTVPLTGPHDPSSAELASEQTHTGDLEESSSTSEHTEDDEDYEG 809

  Fly    97 -EEQRLVVSRILQHCVVDNKNRLRVATPPQQ------------LAHFNR--SSQAEKVPAPSGQM 146
             |.:....||.....:.:|.|...|....:|            ...|.|  :|..:::...:.||
Zfish   810 DEGEEHTQSRPASLHMQNNNNNTAVVQRSEQSQEMQTLSSTADAGGFMRTCTSTVQQISTATTQM 874

  Fly   147 ADEPWLDREAPVLFD-------------------------------------DRILRLGAVDARN 174
            .     |.:.|::.|                                     ||.|.:|. ||::
Zfish   875 T-----DYKTPIVLDSGSGLMKAGFADQDLPAAVFPTVIGRPKYEEVMNSCVDRELYVGH-DAQH 933

  Fly   175 ----YDIHFPIQRGELNVHNEKGGSLQASMQHLERIWSYALEERLKIPLRKLGTHCAVLVVNDVY 235
                ..:.:||:.|.::..:|           :|.:|::|.:.....|    ..|..:|....:.
Zfish   934 MRGVLTLRYPIRHGVVSNWDE-----------MEMLWTHAFQLLSAAP----EDHPVLLTEAALN 983

  Fly   236 VRRHLREFVTLLLRRLGFRRCFLVQDSVASTFGAGIGYGCVVDIGAQKTSIACIEDGISQLDARV 300
            ..::.:..|.|:.........|:...:|.:.:.:|...|.|:|.|...:....:.:|.....|..
Zfish   984 PLQNRQRMVELMFEAFSVPLTFVAVQAVLALYASGRTTGVVLDSGDGVSHSVPVFEGYCLPHAVQ 1048

  Fly   301 RLSYGGGDLDQVLLLLLRKCGFPYRECNVQESYVDAHLLDELKEKFCHLNA---SVCGAQEKHFN 362
            ||...|.|:...|..||.:.|...|      :..:..::.|:||:.|.::.   :...:.|....
Zfish  1049 RLDLAGADVTLQLQKLLLESGVCLR------TSAELEIVREMKERCCFVSVDYEAEMKSSESEIQ 1107

  Fly   363 LRKHNGQWLRYTIQVGDEALMAPLALFHTELLNITGRTKAVFTQQAVQDQYDCEDCFDAEYLKET 427
            ....:|    :|:.:..:...||..||..||:   ||           |.|.
Zfish  1108 YTLPDG----HTVPLASQRFRAPEILFRPELI---GR-----------DHYG------------- 1141

  Fly   428 GRKNGVRGGDILQLSTSAGYQPRPQLPVTADDEELIVVDQDETISNCQSQLGAQTAGGQMNSNGC 492

Zfish  1142 ----------------------------------------------------------------- 1141

  Fly   493 YHNGQGLVLPLDQAIIQSINRLSSYETKRKMFGSILLVGSSAKLPGLAAWLEQRISQQVQSEVNV 557
                      |.:::.:||.: |..:.:|...|:|||.|.:..|.|||..|:..:...|..:::.
Zfish  1142 ----------LHESVFRSILQ-SDLDLRRSFVGNILLSGGNTLLSGLAERLQLEVRAMVPLDLSA 1195

  Fly   558 LIK---GMDAGMVAWKGAAIMSVLESARELWISQNDWQRHGLRVL 599
            .::   ..|.....|.|.|.::.|...:..|||..:::..|.:::
Zfish  1196 CVRVSSPPDRDFSVWSGGAALASLPEQQSAWISAAEYEEFGPQIV 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	68/404 (17%)
si:ch211-241j12.3	XP_017207998.2	Neuromodulin_N	<411..625	CDD:331332
si:ch211-241j12.3	XP_017207998.2	ACTIN	878..1245	CDD:214592	80/492 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910