DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp8 and Actr8

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006519372.2	Gene:	Actr8 / 56249	MGIID:	1860775	Length:	686	Species:	Mus musculus

Alignment Length:	615	Identity:	191/615 - (31%)
Similarity:	308/615 - (50%)	Gaps:	65/615 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RHPAPPPIGLPQPQAQPLEAPKIIVIHPGSQHLRIGRAADLNPLTLLHAVAYRRRPGASDRPHHD 77
            :.|..|.: :|:...:.:::..|:||||||..||:|||.|..|:::.|.:|.|          |.
Mouse    27 KRPIVPAL-VPESLQEQIQSNFIVVIHPGSTTLRLGRATDTLPVSVPHVIARR----------HK 80

  Fly    78 PLLPPL--DNVNSNSGL-MVEFEEQR----LVVSRILQHCVVDNKNRLRVATPPQQLAHFNRSSQ 135
            ....||  ||.....|| ..|..|||    .:|.:.:....:.|..| |:...|:|...:|:..:
Mouse    81 QQGQPLYKDNWLLREGLNKPESNEQRQNGLKMVDQAIWSKKMSNGTR-RIPVSPEQTRSYNKQMR 144

  Fly   136 AEKVPAPSGQMADEPWLD--REAPVLFDDRILRLGAVDARNYDIHFPIQRGELNVHNEKGGSLQA 198
                ||.....:...|.:  ::...|..:..|.:..:|.  |:||:||:||:||:|...||||.|
Mouse   145 ----PAILDHCSGNKWTNTSQQPEYLVGEEALYVNPLDC--YNIHWPIRRGQLNIHPGPGGSLTA 203

  Fly   199 SMQHLERIWSYALEERLKIPLRKLGTHCAVLVVNDVYVRRHLREFVTLLLRRLGFRRCFLVQDSV 263
            .:..:|.|||:|:::.|:|||:.|..:..:|::.|:|.::|::|.|.::|.::||....:.|:||
Mouse   204 VLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVHMILMKMGFAGIVVHQESV 268

  Fly   264 ASTFGAGIGYGCVVDIGAQKTSIACIEDGISQLDARVRLSYGGGDLDQVLLLLLRKCGFPYRECN 328
            .:|||:|:...||||:|.||||:.|:|||:|..:.|:.|:|||.|:.:....|:::.|||||||.
Mouse   269 CATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQ 333

  Fly   329 VQESYVDAHLLDELKEKFCHLNASVCGAQEKHFNLRKHNGQWLRYTIQVGDEALMAPLALFHTEL 393
            :... :|..||..|||.||||:..:.|.|:..|.:|..:...|.|..::|||.|.||:|||:...
Mouse   334 LTNK-MDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPAT 397

  Fly   394 LNITGRTKAVFTQQAVQDQYDCEDCFDAEYLKETGRK---NGVRGGDILQLSTSAGYQ-----PR 450
            ..|.|:.......::   |.|.||..|..||..|..|   :.....|....|...|::     ..
Mouse   398 FGIVGQKMTTLQHRS---QGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQS 459

  Fly   451 PQLPVTADDEELIVVDQDETISNCQSQLGAQTAGGQ--------MNSNGCYHNGQGLVLPLDQAI 507
            ..||.....:|   ||...:..:|      ..||.:        |:........:|..|.||:||
Mouse   460 SDLPERLHSQE---VDLASSQGDC------LMAGNESEEALTALMSRKTAISLFEGKALGLDKAI 515

  Fly   508 IQSINRLSSYETKRKMFGSILLVGSSAKLPGLAAWLEQRISQQVQSEVNVLIKGMDAGMVAWKGA 572
            :.|::..||.:||:||:.|||:||..........:|:.||..::......:|:.:|.........
Mouse   516 LHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKVSR 580

  Fly   573 AIMSVLE-SARELWISQNDWQRHGLRVLRE 601
            .::.|.. |.|.:|:.:.        |:||
Mouse   581 LVIPVRRYSLRPVWLHRT--------VMRE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	132/417 (32%)
Actr8	XP_006519372.2	NBD_sugar-kinase_HSP70_actin	160..>400	CDD:388382	97/242 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11286
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2465
Isobase	1	0.950	-	0	Normalized mean entropy	S3387
OMA	1	1.010	-	-		QHG52058
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005819
OrthoInspector	1	1.000	-	-		oto95049
orthoMCL	1	0.900	-	-		OOG6_104893
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R86
SonicParanoid	1	1.000	-	-		X4212
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740