DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp8 and ACTL6B

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_057272.1	Gene:	ACTL6B / 51412	HGNCID:	160	Length:	426	Species:	Homo sapiens

Alignment Length:	409	Identity:	72/409 - (17%)
Similarity:	133/409 - (32%)	Gaps:	131/409 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 VLVVNDVYVRRHLREFVT-LLLRRLGFRRCFLVQDSVASTFGAGIGYGCVVDIGAQKTSIACIED 291
            ||:....:..|..||.:| |:..:......||.:.:|.:.|..|...|.|:|.||..|:...:.|
Human   117 VLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHD 181

  Fly   292 GISQLDARVRLSYGGGDLDQVLLLLLRKCGFPYRECN--VQESYVD---AHLL---DELKEKFCH 348
            |.......|:....|              .|...:|.  .||..:|   .:::   :.::|
Human   182 GYVLQQGIVKSPLAG--------------DFISMQCRELFQEMAIDIIPPYMIAAKEPVRE---- 228

  Fly   349 LNASVCGAQ---EKHFNLRKHNGQWLRY------------TIQVG----DEALMAPLALFHTELL 394
                  ||.   :|...|.:.:..|..|            .:||.    ||.:.|.:...|.|:.
Human   229 ------GAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMP 287

  Fly   395 NITGRTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADD 459
            |            .....|..|.....|.|.:.....|:.|..:|
Human   288 N------------GYNTDYGAERLRIPEGLFDPSNVKGLSGNTML-------------------- 320

  Fly   460 EELIVVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQAIIQSINRLSSYETKRKMF 524
                                                |.|.|      :..||. :...:.:..::
Human   321 ------------------------------------GVGHV------VTTSIG-MCDIDIRPGLY 342

  Fly   525 GSILLVGSSAKLPGLAAWLEQRISQQVQSEVNVLI----KGMDAGMVAWKGAAIMSVLESARELW 585
            ||:::.|.:..|.|....|.:.:||:....:.:.:    ..|:.....|.|.:|::.|.:.:::|
Human   343 GSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMW 407

  Fly   586 ISQNDWQRHGLRVLRERSP 604
            ||:.:::..|.:.:..:.|
Human   408 ISKQEYEEGGKQCVERKCP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	71/406 (17%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	71/407 (17%)
ACTL6B	NP_057272.1	Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250\|UniProtKB:Q99MR0	39..82
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900