DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp8 and actr3

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001003944.1	Gene:	actr3 / 406250	ZFINID:	ZDB-GENE-040428-2	Length:	418	Species:	Danio rerio

Alignment Length:	550	Identity:	103/550 - (18%)
Similarity:	172/550 - (31%)	Gaps:	191/550 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LQHCVVD---NKNRLRVA--TPPQQLAHFNRSSQAEKVPAPSGQMADEPWLDREAPVLFDDRILR 166
            |..||||   ...:|..|  |.||.:.   .|..|.|..|..|..|     .|......||....
Zfish     5 LPACVVDCGTGYTKLGYAGNTEPQFII---PSCIAIKESAKVGDQA-----QRRMMKGVDDLDFY 61

  Fly   167 LG--AVDARNYDIHFPIQRGELNVHNEKGGSLQASMQHLERIWSYALEERLKIPLRKLGTHCAVL 229
            :|  |:|...|...:||:.|.:    |....::..|:.:  |:.|...|.        ..|..:|
Zfish    62 IGDEAIDKPTYATKWPIRHGIV----EDWDLMERFMEQV--IFKYLRAEP--------EDHYFLL 112

  Fly   230 V---VNDVYVRRHLREFVTLLLRRLGFRRCFLVQDSV----ASTFGAGIG----YGCVVDIGAQK 283
            .   :|....|.:..|   ::.........::...:|    ||.....:|    .|.|:|.|...
Zfish   113 TEPPLNTPENREYTAE---IMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGV 174

  Fly   284 TSIACIEDGISQLDARVRLSYGGGDLDQVLLLLLRKCGFPYRECNV--QESYVDAHLLDELKEKF 346
            |.:..:.:|.........:...|.|:......|||:     ||..:  ::|...|   ..:||:|
Zfish   175 THVIPVAEGYVIGSCIKHIPIAGRDITYFTQQLLRE-----REVGIPPEQSLETA---KAVKERF 231

  Fly   347 CHLNASVCGAQEKHFNLRKHNG-QWLR------------YTIQVGDEALMAPLALFHTELLNITG 398
            .:    ||....|.|:....:| :|::            :||.||.|..:.|...||.|..|
Zfish   232 SY----VCPDLVKEFSKYDTDGSKWIKQYTGINTISKKEFTIDVGYERFLGPEIFFHPEFAN--- 289

  Fly   399 RTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADDEELI 463
               ..|||                                               |::    |::
Zfish   290 ---PDFTQ-----------------------------------------------PIS----EVV 300

  Fly   464 VVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQAIIQSINRLSSYETKRKMFGSIL 528
                ||.|.||                           |:|              .:|.::.:|:
Zfish   301 ----DEVIQNC---------------------------PID--------------VRRPLYKNIV 320

  Fly   529 LVGSSAKLPGLAAWLEQRISQQVQS------------------EVNVLIKGMDAGMVAWKGAAIM 575
            |.|.|.........|::.:.:.|.:                  :|.|:...|....| |.|.:::
Zfish   321 LSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGKLKPKPIDVQVITHHMQRYAV-WFGGSML 384

  Fly   576 SVLESARELWISQNDWQRHGLRVLRERSPF 605
            :......::..::.|::..|..:.|....|
Zfish   385 ASTPEFYQVCHTKKDYEEIGPSICRHNPVF 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	74/444 (17%)
actr3	NP_001003944.1	PTZ00280	2..417	CDD:240343	102/549 (19%)
actr3	NP_001003944.1	COG5277	6..410	CDD:227602	100/543 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900