DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp8 and POTEB

DIOPT Version :9

Sequence 1:	NP_573251.1	Gene:	Arp8 / 32769	FlyBaseID:	FBgn0030877	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001264233.1	Gene:	POTEB / 100996331	HGNCID:	33734	Length:	544	Species:	Homo sapiens

Alignment Length:	344	Identity:	71/344 - (20%)
Similarity:	118/344 - (34%)	Gaps:	139/344 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 ASVC-----GAQEKHFNLRKHNGQWLRY---------TIQVG-----DEALMAPLALFHTELLNI 396
            |.||     .|.:|.|:||...|:|..:         |..||     |::.|..|
Human     3 AEVCSMPAASAVKKPFDLRSKMGKWCHHRFPCCRGSGTSNVGTSGDHDDSFMKTL---------- 57

  Fly   397 TGRTKAVFTQQAVQDQYDCEDCFDAEYLKETGRKNGVRGGDILQLSTSAGYQPRPQLPVTADD-- 459
              |:|        ..::.|. ||..  .:.:|:.|....||   ...||..:||  ..|..:|
Human    58 --RSK--------MGKWCCH-CFPC--CRGSGKSNVGTWGD---YDDSAFMEPR--YHVRREDLD 104

  Fly   460 -------------EELIVVDQDETISNCQSQLGAQTAGGQMNSNGCYHNGQGLVLPLDQ------ 505
                         ::|||:.:|..::....|  .:||....::||   |.:.:.|.||:
Human   105 KLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQ--KRTALHLASANG---NSEVVQLLLDRRCQLNV 164

  Fly   506 -------AIIQSIN----------------------------RLSSYETKRKMFGSILLVGS--- 532
                   |:|:::.                            ..:.|...:.|..::||.|:
Human   165 LDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGADIE 229

  Fly   533 SAKLPGLAAWLEQRISQQVQSEVNVLIK-----------GMDAGMVA--WKGAAIMSVL------ 578
            |....||...| ..:.:|.|..|..|||           |..|.::|  ...|:|:::|
Human   230 SKNKCGLTPLL-LGVHEQKQEVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVD 293

  Fly   579 --------ESARELWISQN 589
                    ::|||..:|.:
Human   294 VSSQDLSGQTAREYAVSSH 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp8	NP_573251.1	NBD_sugar-kinase_HSP70_actin	202..603	CDD:302596	71/344 (21%)
POTEB	NP_001264233.1	ANK	130..255	CDD:238125	23/130 (18%)
		ANK 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	135..167		9/36 (25%)
		ANK repeat	137..166	CDD:293786	8/31 (26%)
		ANK 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	168..200		2/31 (6%)
		ANK repeat	168..199	CDD:293786	2/30 (7%)
		ANK	196..320	CDD:238125	25/118 (21%)
		ANK 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	201..233		6/31 (19%)
		ANK repeat	201..232	CDD:293786	6/30 (20%)
		ANK 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	234..266		9/32 (28%)
		ANK repeat	234..265	CDD:293786	9/31 (29%)
		ANK 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	267..299		6/31 (19%)
		ANK repeat	267..298	CDD:293786	6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..457
		SMC_N	<412..>542	CDD:330553
		CCDC144C	489..>542	CDD:317340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900