Protein Alignment Ucp4A and UCP2

DIOPT Version :10

• Sequence 1: NP_573246.1
• Gene: Ucp4A / 32764
• FlyBaseID: FBgn0030872
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 110/307 - (35%)
• Similarity: 166/307 - (54%)
• Gaps: 20/307 - (6%)

  Fly    32 VKFDYADSFACTYIVSVVAASIAELATYPLDLTKTRLQIQGEGAAHSAGKSNMQYRGMVATAFGI 96
            |||..|.:.||          ||:|.|:|||..|.|||||||........::.||||::.|...:
Human    15 VKFLGAGTAAC----------IADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTM 69

  Fly    97 AREEGALKLWQGVTPALYRHVVYSGVRICSYDLMRKEFTQNGTQALPVWKSALCGVTAGAVAQWL 161
            .|.||...|:.|:...|.|.:.::.|||..||.: |:|...|::...:....|.|.|.||:|..:
Human    70 VRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSV-KQFYTKGSEHASIGSRLLAGSTTGALAVAV 133

  Fly   162 ASPADLVKVQIQMEGRRRLMGEPPRVHSAGHAFRQIVQRGGIKGLWKGSIPNVQRAALVNLGDLT 226
            |.|.|:|||:.|.:.|   .|...|..|..:|::.|.:..|.:|||||:.|||.|.|:||..:|.
Human   134 AQPTDVVKVRFQAQAR---AGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195

  Fly   227 TYDTIKHLIMNRLQMPDCHTVHVLASVCAGFVAAIMGTPADVVKTRIMNQPTDENGRGLLYRGSV 291
            |||.||..::....|.|....|..::..|||...::.:|.||||||.||....:      |..:.
Human   196 TYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQ------YSSAG 254

  Fly   292 DCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFWLSFEQIRKMIGAS 338
            .|....:.|||..|.||||:|.::|:..|::..::::||:::.:.|:
Human   255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAA 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_573246.1	Mito_carr	39..138	CDD:395101	36/98 (37%)
		Mito_carr	142..239	CDD:395101	38/96 (40%)
		Mito_carr	248..336	CDD:395101	28/87 (32%)
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	40/106 (38%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		39/101 (39%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		24/56 (43%)
		transmembrane domain	17..34		8/26 (31%)
		transmembrane domain	78..100		7/21 (33%)
		Mito_carr	112..206	CDD:395101	38/96 (40%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		38/91 (42%)
		transmembrane domain	120..137		7/16 (44%)
		transmembrane domain	174..197		13/22 (59%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		29/90 (32%)
		transmembrane domain	216..235		4/18 (22%)
		Mito_carr	217..299	CDD:395101	28/87 (32%)
		purine nucleotide binding domain	264..273		5/8 (63%)
		transmembrane domain	269..291		7/21 (33%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		2/6 (33%)