DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and Slc25a11

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_077173.1	Gene:	Slc25a11 / 67863	MGIID:	1915113	Length:	314	Species:	Mus musculus

Alignment Length:	332	Identity:	94/332 - (28%)
Similarity:	156/332 - (46%)	Gaps:	43/332 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSNPAPSSGRHQLRP------VKFDYADSFACTYIVSVVAASIAELATYPLDLTKTRLQIQGEGA 75
            ::..:|.:||...:|      |||          :...:|...|.:...||||.|.|:|:.||||
Mouse     2 AATASPGAGRMDGKPRTSPKSVKF----------LFGGLAGMGATVFVQPLDLVKNRMQLSGEGA 56

  Fly    76 AHSAGKSNMQYRGMVATAFGIAREEGALKLWQGVTPALYRHVVYSGVRICSYDLMRKEFTQNGTQ 140
                  ...:|:........|.:.||...::.|::..|.|...|:..|:..|.::.:..|  |..
Mouse    57 ------KTREYKTSFHALTSILKTEGLKGIYTGLSAGLLRQATYTTTRLGIYTVLFERLT--GAD 113

  Fly   141 ALP--VWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRLMGEPPRVH-SAGHAFRQIVQRGG 202
            ..|  ....||.|:||||...::.:||::..:::..:|  ||..:..|.: :..:|..:|.:..|
Mouse   114 GTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADG--RLPADQRRGYKNVFNALVRIAREEG 176

  Fly   203 IKGLWKGSIPNVQRAALVNLGDLTTYDTIKHLIMNRLQMPDCHTVHVLASVCAGFVAAIMGTPAD 267
            :..||:|.||.:.||.:||...|.:|...|..:::.....|....|..||:.:|.|......|.|
Mouse   177 VPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVD 241

  Fly   268 VVKTRIMN------QPTDENGRGLLYRGSVDCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFWL 326
            :|||||.|      :|..:||        :|.|.:.|..|||.:|:|||.|.:.|:.|.::..::
Mouse   242 IVKTRIQNMRMIDGKPEYKNG--------LDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFI 298

  Fly   327 SFEQIRK 333
            ..||:.|
Mouse   299 FLEQMNK 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	87/304 (29%)
		Mito_carr	39..138	CDD:278578	24/98 (24%)
		Mito_carr	142..239	CDD:278578	29/99 (29%)
		Mito_carr	248..336	CDD:278578	32/92 (35%)
Slc25a11	NP_077173.1	Solcar 1	23..108		26/100 (26%)
		Mito_carr	24..102	CDD:278578	24/93 (26%)
		Mito_carr	116..213	CDD:278578	29/98 (30%)
		Solcar 2	117..208		28/92 (30%)
		Mito_carr	215..309	CDD:278578	33/99 (33%)
		Solcar 3	217..306		33/97 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810