DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and slc25a27

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001011241.1	Gene:	slc25a27 / 496683	XenbaseID:	XB-GENE-1005902	Length:	319	Species:	Xenopus tropicalis

Alignment Length:	300	Identity:	181/300 - (60%)
Similarity:	229/300 - (76%)	Gaps:	3/300 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YIVSVVAASIAELATYPLDLTKTRLQIQGEGAAHSAGK--SNMQYRGMVATAFGIAREEGALKLW 106
            :|:|..|||:|||.|:||||||||||||||.|....|:  |.:.|||||.||.||.:|||.||||
Frog    20 FILSACAASVAELVTFPLDLTKTRLQIQGEAALKRHGEVGSAVPYRGMVRTATGIVQEEGLLKLW 84

  Fly   107 QGVTPALYRHVVYSGVRICSYDLMRKEFTQNGT-QALPVWKSALCGVTAGAVAQWLASPADLVKV 170
            ||.|||:|||:||||||:.:|:.:|......|. ...|:|||.:.|:||||:.|:.|||.|||||
Frog    85 QGATPAVYRHIVYSGVRMVAYEHIRDSVLGKGDGDTFPLWKSVVGGMTAGAIGQFFASPTDLVKV 149

  Fly   171 QIQMEGRRRLMGEPPRVHSAGHAFRQIVQRGGIKGLWKGSIPNVQRAALVNLGDLTTYDTIKHLI 235
            |:||||:|||.|:||||....|||..||.:|||:|||.|.:||||||||||:|||||||.:||.:
Frog   150 QMQMEGKRRLEGKPPRVRGVYHAFVTIVSKGGIRGLWAGWVPNVQRAALVNMGDLTTYDMVKHFL 214

  Fly   236 MNRLQMPDCHTVHVLASVCAGFVAAIMGTPADVVKTRIMNQPTDENGRGLLYRGSVDCLRQTVSK 300
            :....:.|....|.::|:|:|.|||.:||||||:||||||||.|::||||||:.|.|||.|.:..
Frog   215 LRNTPIKDNSLCHTISSICSGVVAATLGTPADVIKTRIMNQPRDKHGRGLLYKSSTDCLIQAIRG 279

  Fly   301 EGFVALYKGFLPCWIRMAPWSLTFWLSFEQIRKMIGASGY 340
            |||::|||||:|.|:|||||||.|||::||||::.|.|.:
Frog   280 EGFMSLYKGFMPTWMRMAPWSLVFWLTYEQIRRLGGVSSF 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	179/293 (61%)
		Mito_carr	39..138	CDD:278578	58/95 (61%)
		Mito_carr	142..239	CDD:278578	62/96 (65%)
		Mito_carr	248..336	CDD:278578	57/87 (66%)
slc25a27	NP_001011241.1	Mito_carr	18..114	CDD:365909	58/93 (62%)
		Mito_carr	122..216	CDD:365909	62/93 (67%)
		Mito_carr	223..313	CDD:365909	57/89 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4859
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12523
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2021
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013743at2759
OrthoFinder	1	1.000	-	-		FOG0004436
OrthoInspector	1	1.000	-	-		otm48174
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3442
SonicParanoid	1	1.000	-	-		X3722
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090