DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and aralar1

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001247368.1	Gene:	aralar1 / 43616	FlyBaseID:	FBgn0028646	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	94/358 - (26%)
Similarity:	156/358 - (43%)	Gaps:	67/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPAVASSTSSNPAP----SSGRHQLRPVK----------FDYADSFACTYIVSVVAASIAELATY 59
            |..:..|..||.||    ....|:|..:|          |......:..:.:...|.::.....|
  Fly   309 SSRIDYSDLSNIAPEHYTKHMTHRLAEIKAVESPADRSAFIQVLESSYRFTLGSFAGAVGATVVY 373

  Fly    60 PLDLTKTRLQIQGEGAAHSAGKSNMQYRGMVATAFG------IAREEGALKLWQGVTPALYRHVV 118
            |:||.|||:|.|..|:          |.|.||....      :.|.||.:.|::|:.|.|.....
  Fly   374 PIDLVKTRMQNQRAGS----------YIGEVAYRNSWDCFKKVVRHEGFMGLYRGLLPQLMGVAP 428

  Fly   119 YSGVRICSYDLMRKEFT-QNGTQALPVWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRLMG 182
            ...:::...||:|.:.| :.|.  :|.|...|.|..|||......:|.::||:::|:.|.
  Fly   429 EKAIKLTVNDLVRDKLTDKKGN--IPTWAEVLAGGCAGASQVVFTNPLEIVKIRLQVAGE----- 486

  Fly   183 EPPRVHSAGHAFR--QIVQRGGIKGLWKGSIPNVQRAALVNLGDL----TTYDTIKHLIMNRLQM 241
                 .::|...|  .:|:..|:.||:||:     ||.|  |.|:    ..:.|..|   .:..|
  Fly   487 -----IASGSKIRAWSVVRELGLFGLYKGA-----RACL--LRDVPFSAIYFPTYAH---TKAMM 536

  Fly   242 PD----CHTVHVLAS-VCAGFVAAIMGTPADVVKTRIMNQPTDENGRGLLYRGSVDCLRQTVSKE 301
            .|    .|.:.:||: ..||..||.:.|||||:|||:  |....:|: ..|.|..|..::.:::|
  Fly   537 ADKDGYNHPLTLLAAGAIAGVPAASLVTPADVIKTRL--QVVARSGQ-TTYTGVWDATKKIMAEE 598

  Fly   302 GFVALYKGFLPCWIRMAPWSLTFWLSFEQIRKM 334
            |..|.:||......|.:|......:::|.::::
  Fly   599 GPRAFWKGTAARVFRSSPQFGVTLVTYELLQRL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	84/314 (27%)
		Mito_carr	39..138	CDD:278578	26/105 (25%)
		Mito_carr	142..239	CDD:278578	27/102 (26%)
		Mito_carr	248..336	CDD:278578	27/88 (31%)
aralar1	NP_001247368.1	EF-hand_7	35..99	CDD:290234
		EF-hand_8	51..99	CDD:290545
		EF-hand_7	81..134	CDD:290234
		EFh	84..135	CDD:298682
		EF-hand_7	111..173	CDD:290234
		Mito_carr	350..448	CDD:278578	26/107 (24%)
		PTZ00169	358..631	CDD:240302	84/307 (27%)
		Mito_carr	449..539	CDD:278578	29/111 (26%)
		Mito_carr	544..633	CDD:278578	28/91 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840