DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and SCaMC

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	70/376 - (18%)
Similarity:	142/376 - (37%)	Gaps:	101/376 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 APSSGRHQLRPVKF-----------------DYADSFACT------YIVSVVAASIAELATYPLD 62
            |||:..|.|  :||                 |:......|      .:...:|.:::...|.|||
  Fly   245 APSTDIHDL--IKFWRHSTYLDIGEDMNVPDDFTQKEMQTGLWWRHLVAGGIAGAVSRTCTAPLD 307

  Fly    63 LTKTRLQIQGEGAAHSAGKSNMQYRGMVATAFGIAREEGALKLWQGVTPALYRHVVYSGVRICSY 127
            ..|..||:|            .|..|:......:..|.|:..:|:|....:.:....:..:..:|
  Fly   308 RIKVYLQVQ------------TQRMGISECMHIMLNEGGSRSMWRGNGINVLKIAPETAFKFAAY 360

  Fly   128 DLMRKEFT-QNGTQALPVWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRLMGEPPRVHSAG 191
            :.|::... .:|::.:.:.:....|..||.::|.:..|.:::|.::.:....:..|       ..
  Fly   361 EQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRLALRRTGQYAG-------IA 418

  Fly   192 HAFRQIVQRGGIKGLWKGSIPNVQRAALVNLG-------DLTTYDTIKHLIM---NRLQMPDCHT 246
            .|..:|.::.|::..::|.:||:       ||       ||..|:|:|...:   :..:.|.
  Fly   419 DAAVKIYKQEGVRSFYRGYVPNI-------LGILPYAGIDLAVYETLKRRYIANHDNNEQPS--- 473

  Fly   247 VHVLASVCAGFVAAIMGT----PADVVKTRIMNQPT----------------------DENGRGL 285
              .|..:..|..::.:|.    |..:|:||:..|..                      :|...||
  Fly   474 --FLVLLACGSTSSTLGQLCSYPLALVRTRLQAQAAETIANQKRKTQIPLKSSDAHSGEETMTGL 536

  Fly   286 LYRGSVDCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFWLSFEQIRKMIG 336
                    .|:.|.:||...||:|..|.::::.|.....::.:|...:.:|
  Fly   537 --------FRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRALG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	61/338 (18%)
		Mito_carr	39..138	CDD:278578	18/105 (17%)
		Mito_carr	142..239	CDD:278578	20/106 (19%)
		Mito_carr	248..336	CDD:278578	21/113 (19%)
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455	1/1 (100%)
		EFh	116..176	CDD:238008
		EFh	186..242	CDD:238008
		Mito_carr	285..370	CDD:278578	17/96 (18%)
		Mito_carr	375..463	CDD:278578	20/101 (20%)
		Mito_carr	470..581	CDD:278578	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930