DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and slc25a34

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_956874.1	Gene:	slc25a34 / 393552	ZFINID:	ZDB-GENE-040426-1442	Length:	319	Species:	Danio rerio

Alignment Length:	325	Identity:	102/325 - (31%)
Similarity:	163/325 - (50%)	Gaps:	18/325 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVASSTSSNPAPSSGRHQLRPVKFDYADSFACTYIVSVVAASIAELATYPLDLTKTRLQIQGEGA 75
            |.:..:|..|.||..|..|.| ..|:.        :..:|...|.:.|.||::.|||||:|||
Zfish     4 AFSGPSSPTPGPSPPRPPLWP-PLDFG--------LGALACCGACVFTNPLEVVKTRLQLQGE-- 57

  Fly    76 AHSAGKSNMQYRGMVATAFGIAREEGALKLWQGVTPALYRHVVYSGVRICSYDLMRKEFTQNGTQ 140
            ..:.|.....|||::...:.:.|.:|...|.:|:|.||....:.:|:|:.||..|:.....:|..
Zfish    58 LRARGSYRRLYRGVLQALWVVGRTDGLRGLQKGLTAALLYQGLMNGLRLGSYAQMQAAGVTDGPC 122

  Fly   141 ALPVWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRL-MGEPPRVHSAGHAFRQIVQRGGIK 204
            .     |.:.|..|||:..::||||.|||..:|.:....: :|..........|...|.:|.|:.
Zfish   123 C-----SLIAGAAAGALGAFIASPAYLVKTHLQAQTVAAIAVGHQHNHQGMSSALVSIYRREGVC 182

  Fly   205 GLWKGSIPNVQRAALVNLGDLTTYDTIKHLIMNRLQMPDCHTVHVL-ASVCAGFVAAIMGTPADV 268
            |||:|....|.|..:.:...|.|:.:.|..|.:........:::.| |:|.:|...:|:.||.||
Zfish   183 GLWRGVNGAVPRVMVGSATQLATFSSAKDWITHTQWFSPLSSLNTLCAAVMSGVAVSIIMTPFDV 247

  Fly   269 VKTRIMNQPTDENGRGLLYRGSVDCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFWLSFEQIRK 333
            :.||:.|||.|:..:|.||.|.||||.:..:.||.:.||||..|.::|:||.:....|.::.:|:
Zfish   248 ISTRLYNQPVDQFKQGRLYCGFVDCLLKVCAAEGVLGLYKGMTPVFVRLAPHTTLSMLLWDVLRQ 312

Fly 334 333
Zfish 313 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	93/297 (31%)
		Mito_carr	39..138	CDD:278578	29/98 (30%)
		Mito_carr	142..239	CDD:278578	28/97 (29%)
		Mito_carr	248..336	CDD:278578	35/87 (40%)
slc25a34	NP_956874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		6/17 (35%)
		Solcar 1	22..115		32/103 (31%)
		Mito_carr	27..113	CDD:278578	29/95 (31%)
		Solcar 2	119..212		28/97 (29%)
		Mito_carr	<141..215	CDD:278578	21/73 (29%)
		Mito_carr	220..311	CDD:278578	34/90 (38%)
		Solcar 3	222..313		35/91 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013743at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920