DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ucp4A and ucp-4

DIOPT Version :9

Sequence 1:	NP_001188664.1	Gene:	Ucp4A / 32764	FlyBaseID:	FBgn0030872	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_505414.1	Gene:	ucp-4 / 179315	WormBaseID:	WBGene00006729	Length:	324	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	152/340 - (44%)
Similarity:	208/340 - (61%)	Gaps:	28/340 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVASSTSSNPAPSSGRHQLRPVKFDYADSFACTYIVSVVAASIAELATYPLDLTKTRLQIQGEGA 75
            :..:|||.:.||.:.:         .....|..|.:|..||.:||..|||||:|||||||
Worm     3 SAVTSTSDSTAPGNSQ---------TFKKIATKYFLSCTAALVAETVTYPLDITKTRLQI----- 53

  Fly    76 AHSAGKSNMQYRGMVATAFGIAREEGALKLWQGVTPALYRHVVYSGVRICSYDLMR-KEFTQNGT 139
                .::.....|||...:.|.|.|||:.||.||.||:.||.:|:|:|:.:|:.:| ..|.:...
Worm    54 ----ARNKFTKGGMVQVTYDIIRREGAMALWTGVAPAITRHYIYTGIRMGAYEQIRLLTFNKEVE 114

  Fly   140 QALPVWKSALCGVTAGAVAQWLASPADLVKVQIQMEGRRRLMGEPPRVHSAGHAFRQIVQRGGIK 204
            ::.|:|||.|||..:|.:||:.|||.||||||:||||.|||..:|.|...|...||.:.:..|..
Worm   115 KSFPLWKSMLCGAFSGLIAQFAASPTDLVKVQMQMEGLRRLQKQPLRYTGATDCFRSLYRTQGFF 179

  Fly   205 GLWKGSIPNVQRAALVNLGDLTTYDTIKHLIMNRLQMPDCHTVHVLASVCAGFVAAIMGTPADVV 269
            |||.|.:||.|||||:|:.|:.|||::||.:::..::.|....|.:||.|||..|||:..|:|||
Worm   180 GLWIGWMPNCQRAALLNMADIATYDSVKHGLIDNFELKDNWLTHAVASACAGLAAAIVSLPSDVV 244

  Fly   270 KTRIMNQPTDE---------NGRGLLYRGSVDCLRQTVSKEGFVALYKGFLPCWIRMAPWSLTFW 325
            |||:|:|...|         |....||:|.|||..:.:..|||.:|||||||.:|||||||||||
Worm   245 KTRMMDQIRHELDAKMMHKKNTHVDLYKGVVDCYIKIIKNEGFFSLYKGFLPSYIRMAPWSLTFW 309

  Fly   326 LSFEQIRKMIGASGY 340
            :|:|:|||..|||.:
Worm   310 VSYEEIRKWTGASSF 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ucp4A	NP_001188664.1	PTZ00169	39..335	CDD:240302	144/305 (47%)
		Mito_carr	39..138	CDD:278578	41/99 (41%)
		Mito_carr	142..239	CDD:278578	50/96 (52%)
		Mito_carr	248..336	CDD:278578	52/96 (54%)
ucp-4	NP_505414.1	PTZ00169	20..317	CDD:240302	142/305 (47%)
		Mito_carr	22..111	CDD:278578	41/97 (42%)
		Mito_carr	115..214	CDD:278578	50/98 (51%)
		Mito_carr	<240..318	CDD:278578	42/77 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166381
Domainoid	1	1.000	108	1.000	Domainoid score	I4050
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12523
Inparanoid	1	1.050	288	1.000	Inparanoid score	I1707
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59581
OrthoDB	1	1.010	-	-		D1013743at2759
OrthoFinder	1	1.000	-	-		FOG0004436
OrthoInspector	1	1.000	-	-		otm14299
orthoMCL	1	0.900	-	-		OOG6_105732
Panther	1	1.100	-	-	LDO	PTHR45618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3442
SonicParanoid	1	1.000	-	-		X3722
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800