DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8142 and RFC4

DIOPT Version :9

Sequence 1:	NP_573245.1	Gene:	CG8142 / 32763	FlyBaseID:	FBgn0030871	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_002907.1	Gene:	RFC4 / 5984	HGNCID:	9972	Length:	363	Species:	Homo sapiens

Alignment Length:	359	Identity:	193/359 - (53%)
Similarity:	253/359 - (70%)	Gaps:	12/359 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAFLK-TGKSTAGSGDKSQGTPAA-------RRKPPAPWVEKYRPRNVDDVVEQSEVVAVLRKC 57
            |||||| |..||.....|.:|..|:       ::..|.||||||||:.||:|..|.||||||:|.
Human     1 MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLKKS 65

  Fly    58 VEGGDLPNMLLYGPPGTGKTSTILAASRQIFG-DMFKDRILELNASDERGINVVRTKIKNFSQLS 121
            :||.||||:|.|||||||||||||||:|::|| ::|:.|:|||||||||||.|||.|:|||:||:
Human    66 LEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLT 130

  Fly   122 ASSVRPDGKPCPPFKIIILDEADSMTHAAQSALRRTMEKESRSTRFCLICNYVSRIIVPITSRCS 186
            .|..|.||||||||||:|||||||||.|||:||||||||||::||||||||||||||.|:|||||
Human   131 VSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCS 195

  Fly   187 KFRFKALGEDKVIDRLKYICEMEGVKIEDDAYKSIVKISGGDLRRAITTLQSCYRLKGPEHIINT 251
            |||||.|.:.....||..|.:.|.|||.|:....:||:|.||||:|||.|||..||.|.:.|...
Human   196 KFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEK 260

  Fly   252 ADLFEMSGVIPEYYLEDYLEVCRSGNYERLEQFVREIGFSAYSVGQMMEQFVEFIVHHPGLNDPQ 316
            . :.:::||||...::.....|:||::::||..|:::....::..|::.|..:.:|.: .|:|.|
Human   261 V-ITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVVEN-NLSDKQ 323

  Fly   317 KATICDKLGECCFRLQDGGSEYLQIMDLGCCIIL 350
            |:.|.:||.|....|.||..|:||::.| |..::
Human   324 KSIITEKLAEVDKCLADGADEHLQLISL-CATVM 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8142	NP_573245.1	rfc	31..344	CDD:234763	178/313 (57%)
		AAA	45..187	CDD:99707	108/142 (76%)
		AAA_assoc_2	211..>256	CDD:292811	21/44 (48%)
		Rep_fac_C	<293..344	CDD:285713	17/50 (34%)
RFC4	NP_002907.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		12/34 (35%)
RFC4	NP_002907.1	Rad17	39..353	CDD:330523	179/316 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160162
Domainoid	1	1.000	203	1.000	Domainoid score	I2978
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6288
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2240
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53599
OrthoDB	1	1.010	-	-		D1071197at2759
OrthoFinder	1	1.000	-	-		FOG0000505
OrthoInspector	1	1.000	-	-		oto89393
orthoMCL	1	0.900	-	-		OOG6_101335
Panther	1	1.100	-	-	LDO	PTHR11669
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770