DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8142 and RAD17

DIOPT Version :9

Sequence 1:	NP_573245.1	Gene:	CG8142 / 32763	FlyBaseID:	FBgn0030871	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_579917.1	Gene:	RAD17 / 5884	HGNCID:	9807	Length:	681	Species:	Homo sapiens

Alignment Length:	419	Identity:	82/419 - (19%)
Similarity:	143/419 - (34%)	Gaps:	135/419 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KTGKSTAGSGDKSQGTPAARR-------------------KPPAPWVEKYRP----------RNV 41
            |.|.||.    :|...||.:|                   ....|||:||:|          :.:
Human    50 KNGPSTL----ESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKI 110

  Fly    42 DDVVEQSEVVAVLRKCVEGGDLPNMLLYGPPGTGKTSTILAASRQ-----------IFGDMFKDR 95
            ::|....:...:.|:..:||.:  :|:.||||.|||:|:...|::           :..|..||
Human   111 EEVETWLKAQVLERQPKQGGSI--LLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD- 172

  Fly    96 ILELNASDERGI---------------------NVVRTKIKNFSQLSASSVRPDGKPCPPFKIII 139
                   |.:|:                     .::|....|..|:....:|.|.      |||:
Human   173 -------DFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDK------KIIL 224

  Fly   140 LDEADSMTHAAQSALRRTMEKESRSTRFCLICNYVS---------RIIVP--ITSRC--SKFRFK 191
            :::..:..:.....|...:.|..|..| |.:...:|         |::.|  |...|  |...|.
Human   225 VEDLPNQFYRDSHTLHEVLRKYVRIGR-CPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFN 288

  Fly   192 ALGEDKVIDRLKYICEME----GVKI---EDDAYKSIVKISGGDLRRAITTLQ------------ 237
            .:....::..|..|..:|    |.||   :..:.:.:.:...||:|.||.:||
Human   289 PVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLRP 353

  Fly   238 --------------SCYRLKGPEHIINTADLFEMSGVIPEYYLEDYLE---VCRSGNYERLEQFV 285
                          ...|.|.|:.:....::..:.|.....:|...|.   .|:..:...|:...
Human   354 RKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPR 418

  Fly   286 REIGFSAYSVGQMM---EQFVEFIVHHPG 311
            .....|.|....::   |:.|| :.|.||
Human   419 LPSHLSEYERDTLLVEPEEVVE-MSHMPG 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8142	NP_573245.1	rfc	31..344	CDD:234763	74/375 (20%)
		AAA	45..187	CDD:99707	36/186 (19%)
		AAA_assoc_2	211..>256	CDD:292811	12/73 (16%)
		Rep_fac_C	<293..344	CDD:285713	7/22 (32%)
RAD17	NP_579917.1	rad24	13..652	CDD:129690	82/419 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..61		5/14 (36%)
		AAA_16	111..258	CDD:289934	32/163 (20%)
		NK	135..>193	CDD:302627	14/65 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		3/32 (9%)
		Interaction with MCM7. /evidence=ECO:0000269\|PubMed:15538388	432..681		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910