DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8142 and rfc2

DIOPT Version :9

Sequence 1:	NP_573245.1	Gene:	CG8142 / 32763	FlyBaseID:	FBgn0030871	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_594540.1	Gene:	rfc2 / 2541908	PomBaseID:	SPAC23D3.02	Length:	340	Species:	Schizosaccharomyces pombe

Alignment Length:	346	Identity:	156/346 - (45%)
Similarity:	217/346 - (62%)	Gaps:	16/346 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAFLKTGKSTAGSGDKSQGTPAARRKPPAPWVEKYRPRNVDDVVEQSEVVAVLRKCVEGGDLPN 65
            |..|....|.|.....||           .||||.|||:.:|.|..|...|.||:|.:...:||:
pombe     1 MSFFAPRNKKTEQEAKKS-----------IPWVELYRPKTLDQVSSQESTVQVLKKTLLSNNLPH 54

  Fly    66 MLLYGPPGTGKTSTILAASRQIFG-DMFKDRILELNASDERGINVVRTKIKNFSQLSASSVRPDG 129
            ||.||.|||||||||||.||::|| .:.|.|:|||||||||||:::|.|:|:|::.:.:: :.||
pombe    55 MLFYGSPGTGKTSTILALSRELFGPQLMKSRVLELNASDERGISIIREKVKSFAKTTVTN-KVDG 118

  Fly   130 KPCPPFKIIILDEADSMTHAAQSALRRTMEKESRSTRFCLICNYVSRIIVPITSRCSKFRFKALG 194
            .|||||||||||||||||..||:|||||||..:|.|||||||||::|||.|::|||||:|||.|.
pombe   119 YPCPPFKIIILDEADSMTQDAQAALRRTMESYARITRFCLICNYMTRIIDPLSSRCSKYRFKPLD 183

  Fly   195 EDKVIDRLKYICEMEGVKIEDDAYKSIVKISGGDLRRAITTLQSCYRL-KGPEHIINTADLFEMS 258
            .:.::.||::|...:.|.:|.....::|:.||||:|:|||.|||...| :|....|::.:  |::
pombe   184 NENMVKRLEFIAADQAVSMEPGVVNALVECSGGDMRKAITFLQSAANLHQGTPITISSVE--ELA 246

  Fly   259 GVIPEYYLEDYLEVCRSGNYERLEQFVREIGFSAYSVGQMMEQFVEFIVHHPGLNDPQKATICDK 323
            |.:|...:...|:...:.|...:|...|::....||.|.::.|..:.::....|:.|.|..|..|
pombe   247 GAVPYNIIRSLLDTAYTKNVSNIETLSRDVAAEGYSTGIILSQLHDVLLKEETLSSPVKYKIFMK 311

  Fly   324 LGECCFRLQDGGSEYLQIMDL 344
            |.|...||.||..|.||::||
pombe   312 LSEVDKRLNDGADETLQLLDL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8142	NP_573245.1	rfc	31..344	CDD:234763	148/314 (47%)
		AAA	45..187	CDD:99707	88/142 (62%)
		AAA_assoc_2	211..>256	CDD:292811	17/45 (38%)
		Rep_fac_C	<293..344	CDD:285713	18/50 (36%)
rfc2	NP_594540.1	rfc	19..337	CDD:234763	150/317 (47%)
		AAA	36..176	CDD:99707	88/140 (63%)
		AAA_assoc_2	197..>247	CDD:292811	18/51 (35%)
		Rep_fac_C	269..334	CDD:285713	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	173	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6288
Inparanoid	1	1.050	289	1.000	Inparanoid score	I640
OMA	1	1.010	-	-		QHG53599
OrthoFinder	1	1.000	-	-		FOG0000505
OrthoInspector	1	1.000	-	-		oto100968
orthoMCL	1	0.900	-	-		OOG6_101335
Panther	1	1.100	-	-	LDO	PTHR11669
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1088
SonicParanoid	1	1.000	-	-		X3510
TreeFam	1	0.960	-	-
	14	13.860