Protein Alignment Socs16D and SOCS6

DIOPT Version :9

• Sequence 1: NP_001259662.1
• Gene: Socs16D / 32760
• FlyBaseID: FBgn0030869
• Length: 1021
• Species: Drosophila melanogaster
• Sequence 2: NP_004223.2
• Gene: SOCS6 / 9306
• HGNCID: 16833
• Length: 535
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 146/583 - (25%)
• Similarity: 207/583 - (35%)
• Gaps: 191/583 - (32%)

  Fly   517 GSGTGAGTETSDGDGEKSKHGKYRTPVGVGMGQVSESEPLHMTLDEVKQFYHTLYSDAGKPTPKP 581
            ||..|....:.|.:||..|.||.|          |:||.|..||.............||.|:.
Human    44 GSCYGKDMASCDINGEDEKGGKNR----------SKSESLMGTLKRRLSAKQKSKGKAGTPSG-- 96

  Fly   582 MVKSSNETIWSVS----------------------------------TNTTTTTARTRSSVGTTR 612
              .|::|..:|.|                                  ||:..|..:....|....
Human    97 --SSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALV 159

  Fly   613 GGGGPPGAGNGAGGASSDGGVGGGSAGGGGGKYLSKQNKHNLDNDKLNNNNNNNNNHQPSQQQLE 677
            ....|..|.||.                       :::.|:|.::.......|:          .
Human   160 HSSSPSPALNGV-----------------------RKDFHDLQSETTCQEQANS----------L 191

  Fly   678 KPPTEHHNQHQPPNNKHV-----LHSEKKSQFTLNLKQRFCSIFRFRRSNHSRCRGSGNNQTGTF 737
            |....|:.......::||     |..:...|:|:.|.:....:    ..:.|.|..|.:
Human   192 KSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPL----EGSRSYCLDSSS------ 246

  Fly   738 ASANANAAATAPLIPPIAVITSAPGAAG------QTQLASEL------------NGTLI------ 778
                           |:.|....|...|      ::|:..:|            ||.||
Human   247 ---------------PMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVM 296

  Fly   779 -----TAEADEPNADLRKKFQSRALPPL------------------------------PKKALPF 808
                 ....|.|..       |..|||:                              |..| |.
Human   297 LQSPRAGHDDVPPL-------SPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSA-PG 353

  Fly   809 TAAAYAIEAVKSEPEEVKTNAIQEPRALQFTSSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSFI 873
            .|..|  ::|:|....|.|:         .|..::|:...||||||::...||..|::.|||||:
Human   354 VARVY--DSVQSSGPMVVTS---------LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFL 407

  Fly   874 VRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSYAKFKSQT-ITEFIEKAVEHSRSGRYLF 937
            |||||||.|:.||||:.:....|.|||...|.|||......:..| |.:.||.::..|.:|.:.:
Human   408 VRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCY 472

  Fly   938 FLHRRPEHGPMRVQLTNPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYLNYKH 1000
            ...|.|......|:||||||||..|:|||::||||| :...|.||||.||||.::.|||..||
Human   473 SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVI-RQYTRIDLIQKLPLPNKMKDYLQEKH 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	42/98 (43%)
		SOCS_SOCS7	960..1009	CDD:239710	23/41 (56%)
SOCS6	NP_004223.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..105		5/28 (18%)
		SH2_SOCS6	373..472	CDD:198250	42/98 (43%)
		SOCS_SOCS6	495..535	CDD:239709	23/41 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9166
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10155
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3554
SonicParanoid	1	1.000	-	-		X1970
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940