DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs16D and SOCS3

DIOPT Version :9

Sequence 1:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001365861.1	Gene:	SOCS3 / 9021	HGNCID:	19391	Length:	225	Species:	Homo sapiens

Alignment Length:	189	Identity:	49/189 - (25%)
Similarity:	90/189 - (47%)	Gaps:	39/189 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 SSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSFIVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQG 904
            :::.|:::.|:||..::...|..:||:||.|:|::|||||..:.|:||.|..:..:::||:.:.|
Human    36 NAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGG 100

  Fly   905 TFSFGSYAKFKSQTITEF--IEKAVEH-------------------------------SRSGRYL 936
            :||..|..: .:|.:..|  :.|.|.|                               ....|..
Human   101 SFSLQSDPR-STQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRA 164

  Fly   937 FFLHRRPEHGPMRVQLTNPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLP-RRLLD 994
            ::::...|..|:  .|:.|:|  .:|.:|||:||..:...:...:.:..||.| |..||
Human   165 YYIYSGGEKIPL--VLSRPLS--SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLD 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	32/129 (25%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710	12/36 (33%)
SOCS3	NP_001365861.1	Kinase inhibitory region (KIR)	22..33
		Extended SH2 subdomain (ESS)	34..45		1/8 (13%)
		SH2_SOCS3	35..135	CDD:198247	31/99 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..162		0/30 (0%)
		SOCS_SOCS3	184..225	CDD:239706	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770