DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs16D and SOCS1

DIOPT Version :9

Sequence 1:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_003736.1	Gene:	SOCS1 / 8651	HGNCID:	19383	Length:	211	Species:	Homo sapiens

Alignment Length:	150	Identity:	50/150 - (33%)
Similarity:	74/150 - (49%)	Gaps:	23/150 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   849 GWYWGPLSSEAAEKVLSSEPDGSFIVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSF-GSYA 912
            |:||||||...|.:.|.:||.|:|:||||...:..|:||.|:.:....:|:....|.|.. ||..
Human    78 GFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRE 142

  Fly   913 KFKSQTITEFIEKAVEHSRSGRYLFFLHRRPEHGPMRVQLTNPVSRFKHVQSLQHMCRFVILKAV 977
            .|  ..:.|.:|..|.                 .|.|: |..|: |.:.|:.||.:||..|:..|
Human   143 SF--DCLFELLEHYVA-----------------APRRM-LGAPL-RQRRVRPLQELCRQRIVATV 186

  Fly   978 IRKDLIQTLPLPRRLLDYLN 997
            .|::|.: :||...|.|||:
Human   187 GRENLAR-IPLNPVLRDYLS 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	30/88 (34%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710	15/37 (41%)
SOCS1	NP_003736.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		Kinase inhibitory region (KIR)	55..66
		Extended SH2 subdomain (ESS)	67..78		50/149 (34%)
		SH2_SOCS1	68..165	CDD:198245	33/106 (31%)
		SOCS_SOCS1	169..211	CDD:239704	15/37 (41%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	173..182		4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770