Protein Alignment Socs16D and Socs5

DIOPT Version :9

• Sequence 1: NP_001259662.1
• Gene: Socs16D / 32760
• FlyBaseID: FBgn0030869
• Length: 1021
• Species: Drosophila melanogaster
• Sequence 2: NP_062628.2
• Gene: Socs5 / 56468
• MGIID: 2385459
• Length: 536
• Species: Mus musculus
• Alignment Length: 591
• Identity: 141/591 - (23%)
• Similarity: 203/591 - (34%)
• Gaps: 183/591 - (30%)

  Fly   479 QQQQQLLVEEQQQQKPAAPTYHKASRRNKRNKRK---------QRYAGSGTGAGTETSDGD---- 530
            ||:...|.|....|...:|: ...||||:....:         ::.:.||...||..:..|
Mouse    53 QQESSPLRENVALQLGLSPS-KTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSR 116

  Fly   531 ----GEKSKHGKYRTPVGVGMGQVSESEPLHMTLDEVKQFYHTLYSDAGKPTPKPMVKSSNETIW 591
                |.|.||              |.|.....:||..|:|
Mouse   117 HAPWGGKKKH--------------SCSTKTQSSLDTEKKF------------------------- 142

  Fly   592 SVSTNTTTTTARTRSSVGTTRGGGGPPGAGNGAGGASSDGGVGGGSAGGGGGKYL---------- 646
                      .||||  |..|        .....|.||...:...|:...|.:.|
Mouse   143 ----------GRTRS--GLQR--------RERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGL 187

  Fly   647 -------SKQNKHNLDNDKLNNNNNNNNNHQPSQQQLEKPP--------TEHH--NQHQPPNNKH 694
                   |||:|...         :|......|:..|||.|        .:.|  .||..|.:.|
Mouse   188 CFPMRTYSKQSKPLF---------SNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPH 243

  Fly   695 ----------VLHSEKKSQFTLNLKQRFCSIFRFRRSNHSRCRGSGNNQTGTF-ASANANAA-AT 747
                      ::.:|.:..   .|::      |.|.|.........|.|..|| |:|..|.. ..
Mouse   244 STFFDTFDPSLVSTEDEED---RLRE------RRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKL 299

  Fly   748 AP-LIPPIAVITSAPGAAGQTQLASELNGTLITAEADEPNADLRKKFQSRALPPLPKKALPFTAA 811
            .| |.|.:..|:....|..||...||.:.|.:.             .|||.     :|....:..
Mouse   300 GPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLC-------------LQSRR-----QKQRQVSGD 346

  Fly   812 AYAIEAVKSEPEEVKTNA----IQEPRALQFTSSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSF 872
            ::| ...:....:|.|..    ...|..||.|.:       ..|||.:....||.:|..:|:|:|
Mouse   347 SHA-HVSRQGAWKVHTQIDYIHCLVPDLLQITGN-------PCYWGVMDRYEAEALLEGKPEGTF 403

  Fly   873 IVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSY--AKFKSQTITEFIEKAVEHSRSGRY 935
            ::|||:.:.|:||:||:..|...|.||||....|||.::  ..|.|.|:|..:|...:.|..
Mouse   404 LLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSC--- 465

  Fly   936 LFFLHRRPEHGPMRVQLTNPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYLNYKH 1000
            :||       .|:.....|....|    |||::||.||.:.. ..|.|..||||..|.|:|...|
Mouse   466 MFF-------EPLLTISLNRTFPF----SLQYICRAVICRCT-TYDGIDGLPLPSMLQDFLKEYH 518

  Fly  1001 CYSEQV 1006
             |.::|
Mouse   519 -YKQKV 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	33/99 (33%)
		SOCS_SOCS7	960..1009	CDD:239710	19/47 (40%)
Socs5	NP_062628.2	Required for interaction with IL4R	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..59		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..175		26/138 (19%)
		SOCS	146..195	CDD:372221	10/58 (17%)
		SH2	370..470	CDD:387587	38/116 (33%)
		SOCS_SOCS5	479..534	CDD:239708	20/51 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810