DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs16D and SOCS4

DIOPT Version :9

Sequence 1:	NP_001259662.1	Gene:	Socs16D / 32760	FlyBaseID:	FBgn0030869	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_543143.1	Gene:	SOCS4 / 122809	HGNCID:	19392	Length:	440	Species:	Homo sapiens

Alignment Length:	397	Identity:	93/397 - (23%)
Similarity:	157/397 - (39%)	Gaps:	83/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 GGKYLSKQNKHNLDND-----KLNNNNNNNNNHQPSQQQ-------LEKPPTEHHNQHQPPNN-- 692
            |.::|.:..|..|.:.     .:.|.::.:::..||:::       |:|.|.       ||.:
Human    83 GHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPF-------PPRSDL 140

  Fly   693 --------KHV--LHSEKKSQFTLNLKQRFCSIFRFRRSN---HSRCRGSGNNQTGTFASANANA 744
                    :|.  ::|:.....:.:|.|......:.:|.|   :..|....|.|.....:.|| .
Human   141 AFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRNMEENINCFSHTNVQPCVITTDNA-L 204

  Fly   745 AATAPLIPPIAVITSAPGAAGQTQLASELNGTLITA--EADEPNADLRKKFQSRALPPLPKKALP 807
            ....|:...:..:.|..........:.:...||.|:  :.::|..||..:......||.....:.
Human   205 CREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEILQLETPPKYHTQID 269

  Fly   808 FTAAAYAIEAVKSEPEEVKTNAIQEPRALQFTSSIEKVKDYGWYWGPLSSEAAEKVLSSEPDGSF 872
            :.....                   |..||       :.:...|||.:...|||.:|..:|:|:|
Human   270 YVHCLV-------------------PDLLQ-------INNNPCYWGVMDKYAAEALLEGKPEGTF 308

  Fly   873 IVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSY--AKFKSQTITEFIEKAVEHSRSGRY 935
            ::|||:.:.|:||:||:..:...|.||||....|||.::  ..|.|..||..:|...:.|..
Human   309 LLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSAC--- 370

  Fly   936 LFFLHRRPEHGPMRVQLTNPVSR-FKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYLNYK 999
            :||       .|:   |:.|:.| |..  ||||:||.||.... ..|.|..||:|..:..||...
Human   371 MFF-------EPL---LSTPLIRTFPF--SLQHICRTVICNCT-TYDGIDALPIPSSMKLYLKEY 422

  Fly  1000 HCYSEQV 1006
            | |..:|
Human   423 H-YKSKV 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	32/99 (32%)
Socs16D	NP_001259662.1	SOCS_SOCS7	960..1009	CDD:239710	18/47 (38%)
SOCS4	NP_543143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		SOCS	59..111	CDD:315310	5/27 (19%)
		SH2_SOCS4	275..375	CDD:198248	37/135 (27%)
		SOCS_SOCS4	384..439	CDD:239707	19/49 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810