DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OdsH and UNCX

DIOPT Version :9

Sequence 1:	NP_523389.3	Gene:	OdsH / 32758	FlyBaseID:	FBgn0026058	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001073930.1	Gene:	UNCX / 340260	HGNCID:	33194	Length:	531	Species:	Homo sapiens

Alignment Length:	373	Identity:	114/373 - (30%)
Similarity:	150/373 - (40%)	Gaps:	156/373 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VQHPH---GSS----------------------ALQLYAAAAAVNMQVSGWSSVLNLSMDAPNPE 57
            ::|||   |.|                      .||..||||:|...:.|
Human     7 LEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAASVPFSIDG--------------- 56

  Fly    58 ISPNSVTNSSSVYMIRQMALIQQARVAAAAVAMQQQQQQQRDLNRELGMDPHSEQRIKLDSVSPT 122
                               |:..:..|||:|                              |:||
Human    57 -------------------LLGGSCAAAASV------------------------------VNPT 72

  Fly   123 HNIHAGSSRGIKQDP--LSDEGADSNLGQNDCTESSKKRRGRTNFNSWQLRELERVFQGSHYPDI 185
            ..:.|....|....|  |||.| |.:.....|    |:||.||||..|||.|||:.|..|||||:
Human    73 PLLPAACGVGGDGQPFKLSDSG-DPDKESPGC----KRRRTRTNFTGWQLEELEKAFNESHYPDV 132

  Fly   186 FMREALATKLDLMEGRIAVWFQNRRAKWRKQEHTKKGPGRPAHNAHPQSCSGDPIPLSELRAREL 250
            |||||||.:|||:|.|:.||||||||||||:|:|||||||||||:||.:|||:|:...|:..:||
Human   133 FMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKEL 197

  Fly   251 AQRSKRMKKAIDRQAKKLQDKGLEVDYARLEAEYLAAHQENGVDENNWLDDDGYDDLHIDVVGVE 315
            .:..|:.:|   .:.|.|:.:|..:            |...|:            .||
Human   198 EKMEKKKRK---HEKKLLKSQGRHL------------HSPGGL------------SLH------- 228

  Fly   316 PEYVTGDSLDHSFCSSRTYQTKSTSSELDSNDMGLQGRVETPPPPQPP 363
                                 .:.||:.||...||     :|.||:||
Human   229 ---------------------SAPSSDSDSGGGGL-----SPEPPEPP 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OdsH	NP_523389.3	Homeobox	162..214	CDD:278475	37/51 (73%)
UNCX	NP_001073930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..107		8/24 (33%)
		Homeobox	108..161	CDD:306543	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..312		43/150 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BD9D
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004658
OrthoInspector	1	1.000	-	-		otm41083
orthoMCL	1	0.900	-	-		OOG6_108739
Panther	1	1.100	-	-	O	PTHR46799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5708
SonicParanoid	1	1.000	-	-		X4373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800