Protein Alignment OdsH and DUX4

DIOPT Version :10

• Sequence 1: NP_523389.3
• Gene: OdsH / 32758
• FlyBaseID: FBgn0026058
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_001280727.1
• Gene: DUX4 / 100288687
• HGNCID: 50800
• Length: 424
• Species: Homo sapiens
• Alignment Length: 88
• Identity: 34/88 - (38%)
• Similarity: 41/88 - (46%)
• Gaps: 12/88 - (13%)

  Fly   159 RRGRTNFNSWQLRELERVFQGSHYPDIFMREALATKLDLMEGRIAVWFQNRRAKWRKQEHTKKGP 223
            ||.||.....|...|.|.|:...:|.|..||.||.:..|.|.||.:|||||||:     |..:|.
Human    95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-----HPGQGG 154

  Fly   224 GRPAH-----NAHPQSCSGDPIP 241
            ..||.     :|.|.  .|.|.|
Human   155 RAPAQAGGLCSAAPG--GGHPAP 175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OdsH	NP_523389.3	Homeodomain	159..215	CDD:459649	25/55 (45%)
DUX4	NP_001280727.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		homeodomain	25..78	CDD:238039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..102		4/6 (67%)
		Homeodomain	95..149	CDD:459649	25/58 (43%)
		PRK07764	<141..319	CDD:236090	16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..362
		Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377	327..424
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..414
		Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456	405..424