DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-4 and alx1

DIOPT Version :9

Sequence 1:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001038539.1	Gene:	alx1 / 565176	ZFINID:	ZDB-GENE-050419-191	Length:	320	Species:	Danio rerio

Alignment Length:	125	Identity:	56/125 - (44%)
Similarity:	72/125 - (57%)	Gaps:	10/125 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 RQSLPPAGPPSEGSNEDGGFPGDGDDDSSAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREA 275
            |.|...:||.....:|.|   ...|.:.|::|:||.||.|.|.||||||:.|..:||||:::||.
Zfish    91 RVSPATSGPDKTDLDELG---EKCDSNVSSSKKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQ 152

  Fly   276 LAMRLDLKESRVAVWFQNRRAKVRKREHTKKGPGRPAHNAQ-------PQTCSGEPIPPN 328
            ||||.:|.|:||.|||||||||.||||...:.....:|.|.       |:|.|...|..|
Zfish   153 LAMRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISMLPRTDSYSQISNN 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	34/52 (65%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	1/2 (50%)
alx1	NP_001038539.1	Homeobox	123..176	CDD:278475	34/52 (65%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	180..320		7/33 (21%)
		OAR	296..313	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	300..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910