DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-4 and uncx4.1

DIOPT Version :9

Sequence 1:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001018616.2	Gene:	uncx4.1 / 553947	ZFINID:	ZDB-GENE-050714-1	Length:	470	Species:	Danio rerio

Alignment Length:	423	Identity:	130/423 - (30%)
Similarity:	170/423 - (40%)	Gaps:	163/423 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 NVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAGPPSEGSNEDG----GFPGDGDDDSSAAKR 243
            ::|..|..:.|||..::..:.:....|:..:..|......|.|.|.    |..||.|.:|...||
Zfish    37 DISGHQLQSAAAVPFSIDGLLNGSCSGSVANSNPLLGSGCGVNGDSQYKLGDGGDPDKESPGCKR 101

  Fly   244 RRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGP 308
            ||:||||..|||||||:|.:.|||||:|||||||:||||.||||.|||||||||.||:|:|||||
Zfish   102 RRTRTNFTGWQLEELEKASNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGP 166

  Fly   309 GRPAHNAQPQTCSGEPIPPNELKAKERARRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQH 373
            ||||||:.|.||||||:.|.|:..:|..|..||..|    |.|||           ||    ||:
Zfish   167 GRPAHNSHPTTCSGEPMDPEEIARRELERLEKKKRK----QERKL-----------LK----SQN 212

  Fly   374 K--ANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGGGGGASSSLH 436
            |  |...|.             ..|:|||                            .|.|.|.
Zfish   213 KLLAGELFH-------------TPGSDSD----------------------------SGVSQST- 235

  Fly   437 CGLDGDGDSSRAGSFIGGGGSLGSPSSVAPPSMLSNGAVQFGKLEPMDGNESEERDRERDSPKPL 501
                 |.:|:                                   |..|
Zfish   236 -----DSEST-----------------------------------PHTG---------------- 244

  Fly   502 LFPAKAFHQLNLQSSQQHHGLVVGQGQGSGSGHGHGHQHNHHQHHLHHGSASASAAA-------- 558
                           .||            |.|....:|...||..|..:::.:..|
Zfish   245 ---------------PQH------------SAHRQQTEHICEQHARHQRASTVNETAEPMDSTRN 282

  Fly   559 ---AVANLVHQTSPISMRRSNPFSIESLLFNNT 588
               ..||.:.:.|  ::::.||||:||||.:::
Zfish   283 SGLCPANGITRAS--TLQKLNPFSVESLLADSS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	41/52 (79%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	13/40 (33%)
uncx4.1	NP_001018616.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..102		6/18 (33%)
		Homeobox	104..157	CDD:278475	41/52 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..185		21/27 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..289		33/233 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004658
OrthoInspector	1	1.000	-	-		mtm6384
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46799
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.100