Protein Alignment unc-4 and E5

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 128/607 - (21%)
• Similarity: 169/607 - (27%)
• Gaps: 280/607 - (46%)

  Fly    15 TNNNNSSASRNN-----NSHNNNNNNHSPKEIPEETGRSSSTSSNSIPNAHRTNAGQHLLGGSPS 74
            ||.|||......     ...::.:.:.||:       ||..:.|.|.|||          ||:|:
  Fly    87 TNTNNSGRRTPRGYIYCRRRDSLDRSRSPQ-------RSPVSRSPSPPNA----------GGNPA 134

  Fly    75 SACSTSVSGCGMPSEGLHPTAALQLYAAAAQLAPNGVRVPPWGPFLQFGVPGVFGPNGPFLGRPR 139
            :|.:|:.||......|..||....|...|..||..|.|..|....::..     ||..|....|.
  Fly   135 AAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMA-----GPPHPPSQPPP 194

  Fly   140 FDAASAGGHPNSAAAAAAATQMAAVNASNAFANLTGLSAAALRNVSAAQTTAVAAVASTVATIQH 204
            |              .||..||||              |.|..:....|.
  Fly   195 F--------------LAAQFQMAA--------------ALAHHHQQQQQQ--------------- 216

  Fly   205 RLMIGNRQSLP--PAGPP-------SEGSNEDGGFPG---------DGDDDSSAA---------- 241
                 .:|.||  |.|||       ..|....|.|||         .|.....:|
  Fly   217 -----QQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPHLIRDSYPL 276

  Fly   242 -------------------------KRRRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLD 281
                                     |.:|.||.|:..||.:||.||..:||.....|:.||..|.
  Fly   277 YPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLS 341

  Fly   282 LKESRVAVWFQNRRAKVRKREHTKKGPGRPAHNAQPQTCSGEPIPPNELKAKERARRRKKLAKAI 346
            |.|::|.|||||||.|
  Fly   342 LTETQVKVWFQNRRTK------------------------------------------------- 357

  Fly   347 DRQARKLQAKGITVDLEALKAEYISQHKANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPV 411
                                      ||               ::...||..||.:.:.
  Fly   358 --------------------------HK---------------RMQQEGGDGSDTKSNK------ 375

  Fly   412 RLGGGGGGGGGTGGGGGGGASSSLHCGLDGDGDSSRAGSFIGGGGSLGSPSSVAPPSMLSNGAVQ 476
                     |.:.||||||         ||:.|:...|                     |..:.:
  Fly   376 ---------GSSSGGGGGG---------DGEDDAKHDG---------------------SQHSYE 401

  Fly   477 FGKLEPMDGNESEERDRER-----DSPKPLLFPAKAFHQLNLQSSQ---QHHGLVVGQGQGSGSG 533
            ..: :|.|.:|.||.|.:.     |....:  .|:...:|..|..|   ||....:.|..|..:.
  Fly   402 DAE-DPEDEDEIEEDDEDEVIDMDDYGSEM--DAEEHQRLREQFQQQLAQHQQQFMQQNAGEAAT 463

  Fly   534 HGHGHQH---NHHQHHL---HH 549
            .....||   ..||.||   ||
  Fly   464 LSPQQQHQLLQQHQQHLQQQHH 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	27/55 (49%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	29/145 (20%)