Protein Alignment unc-4 and ey

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 725
• Identity: 169/725 - (23%)
• Similarity: 248/725 - (34%)
• Gaps: 238/725 - (32%)

  Fly    15 TNNNNSSASRNNNSHNNNNNNHSPKEIPEETGRSSSTSS--NSIPNAHRTNAG---QHLLGGSPS 74
            ||:|..|.|    |.|....|.:.::..:.||..||::|  |||......:.|   .::..||..
  Fly   206 TNDNIPSVS----SINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRG 266

  Fly    75 SACST------------------SVSGCGMPSEGLHPTAAL---QLYAAAAQLAPNGVRVPPWGP 118
            :..|:                  |.||.|...|.::....|   |..|....|.|  .|..|
  Fly   267 TLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEP--ARAAP--- 326

  Fly   119 FLQFGVPGVFGPNGPFLG-RPRFDAASAGGH------------PNSAAAAAAATQMAAVNASNAF 170
                    :.|.:...|| |........|.|            |...:.:...|.::.:..|:|
  Fly   327 --------LVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSA- 382

  Fly   171 ANLTGLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPA-----------GPPS--- 221
            .|:..::|       .|...::|...|....|:....||::::.|.|           |..|
  Fly   383 PNIASVTA-------YASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDET 440

  Fly   222 ---EGSNEDGGFP--GDGDDDSS----AAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREALA 277
               ||.|.:||..  |:.:||.:    ..|.:|:||:|.:.|::.||:.|..:||||:|.||.||
  Fly   441 GSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLA 505

  Fly   278 MRLDLKESRVAVWFQNRRAKVRKRE------HTKKGPGRPAHNAQPQTCSGEPIPPNELKAKERA 336
            .::.|.|:|:.|||.|||||.|:.|      .|....|..|.::.....:.....||.|.|
  Fly   506 GKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSA---- 566

  Fly   337 RRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKANGTFSDSDLEDDGIQIDVVG-GTDSD 400
                                  ...|.:..|...|....||..|.|.|..: :....:| |.||.
  Fly   567 ----------------------CSSLLSGSAGGPSVSTINGLSSPSTLSTN-VNAPTLGAGIDSS 608

  Fly   401 DE------------GDSD----------AVSPVRLGGGG--------GGGGGTG----------- 424
            :.            .|:|          ..||..||.||        ..|...|
  Fly   609 ESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRL 673

  Fly   425 ----GGGGGGASSSLHCGL---DGDGDSSRAGSFIGGGGSLGSPSSVAPPSMLSNGAVQFGKLEP 482
                |..|...|:..|..|   |..|..:...||     :..:...:||||.:.    |.|.|.|
  Fly   674 NFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSF-----NHSAVGPLAPPSPIP----QQGDLTP 729

  Fly   483 MDGNESEERDRERDSPKPLLFPAKAFHQLNLQ---SSQQHHGLVVGQ-GQGSGSGHGHGHQHNHH 543
            ..                 |:|.    .:.|:   .:..||.:|.|. |:.:|.|.|.|...|..
  Fly   730 SS-----------------LYPC----HMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLG 773

  Fly   544 QHHLHHG-------------SASASAA--------AAVANLV-HQT-------SPIS------MR 573
            ......|             .||:|||        :|.||:. |.|       ||.|      :.
  Fly   774 ASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVA 838

  Fly   574 RSNPFSIESL 583
            .|:.||.:.:
  Fly   839 HSSGFSSDPI 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	28/55 (51%)
ey	NP_001014693.1	PAX	98..221	CDD:128645	7/18 (39%)
		Homeodomain	473..528	CDD:459649	28/54 (52%)