Protein Alignment unc-4 and PHOX2A

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_001412025.1
• Gene: PHOX2A / 401
• HGNCID: 691
• Length: 312
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 97/386 - (25%)
• Similarity: 131/386 - (33%)
• Gaps: 145/386 - (37%)

  Fly   150 NSAAAAAAATQMAAVNASNAFANLTGLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSL 214
            ||..:..||.:.:|.....|.:...|...:.||....|......|:.|:...:.   .:.:.|..
Human     7 NSYDSCVAAMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALG---ALRDHQPA 68

  Fly   215 PPAGPPSEGSNEDGGFPGDGDDDSSAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREALAMR 279
            |.:..|.:...|..|.       ....|:||.||.|.|.||:||||.|:.:|||||:.||.||::
Human    69 PYSAVPYKFFPEPSGL-------HEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALK 126

  Fly   280 LDLKESRV----------------------------AVWFQNRRAKVRKREH------------T 304
            :||.|:||                            .|||||||||.||:|.            .
Human   127 IDLTEARVQDLTRALRPRADPVRSPTLVQADWPLCPQVWFQNRRAKFRKQERAASAKGAAGAAGA 191

  Fly   305 KKGPGRPA---HNAQPQTCSGEP-----IPPNELKAKERARRRKKLAKAIDRQARKLQAKGITVD 361
            |||..|.:   .:::..|||..|     :||.                         .|.|:
Human   192 KKGEARCSSEDDDSKESTCSPTPDSTASLPPP-------------------------PAPGL--- 228

  Fly   362 LEALKAEYISQHKANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGG------ 420
                         |:...|.|.|                         ||.||.|.|.|
Human   229 -------------ASPRLSPSPL-------------------------PVALGSGPGPGPGPQPL 255

  Fly   421 ---------GGTGGGGGGGASSSLHCGLDGDGDSSRAGSFIGGGGSLGSPSSVAPPSMLSN 472
                     ||.|||.|.||:..|......:   |..|.|   .|.|.|......|::.:|
Human   256 KGALWAGVAGGGGGGPGAGAAELLKAWQPAE---SGPGPF---SGVLSSFHRKPGPALKTN 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	36/83 (43%)
PHOX2A	NP_001412025.1	Homeodomain	91..175	CDD:459649	36/83 (43%)