Protein Alignment unc-4 and VSX1

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_055403.2
• Gene: VSX1 / 30813
• HGNCID: 12723
• Length: 365
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 114/465 - (24%)
• Similarity: 159/465 - (34%)
• Gaps: 178/465 - (38%)

  Fly    45 TGRSSSTSSNSIPNAHRTNAGQHLLGGSPSSACSTSVSGCGMPSEGLHPT--AALQLYAAAAQL- 106
            |||.|.:..       ||::...:.||||               .|..|.  |...|....|:|
Human     2 TGRDSLSDG-------RTSSRALVPGGSP---------------RGSRPRGFAITDLLGLEAELP 44

  Fly   107 APNGVRVPPWGPFLQFGVPGVFGPN-GPFLGRPRFDAASA---------------GGHPNSAAAA 155
            ||.|   |..|       .|..||. .|..| |..|.:|.               |..|.:||.|
Human    45 APAG---PGQG-------SGCEGPAVAPCPG-PGLDGSSLARGALPLGLGLLCGFGTQPPAAARA 98

  Fly   156 AAATQMAAVNASNAFANLTGLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAG-- 218
            ..                                                |::.:...|||.|
Human    99 PC------------------------------------------------LLLADVPFLPPRGPE 115

  Fly   219 ----------PPSEGSNEDGGFPGDGDDDSSA--------------AKRRRSRTNFNSWQLEELE 259
                      ||:.|..:........|:||.:              .|:||.||.|.:.||||||
Human   116 PAAPLAPSRPPPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTLGKRKKRRHRTVFTAHQLEELE 180

  Fly   260 RAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGPGRPA----HNAQPQTC 320
            :|||.:||||::.||.||::.:|.|.|:.|||||||||.||||....|....|    :.|..:.|
Human   181 KAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHC 245

  Fly   321 SGEPIPPNELKAKERA----------RRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKA 375
            .  |:|.:.|.:.|..          ...||....|.:...:.:..|:          :.|.|..
Human   246 I--PLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGL----------WGSDHFK 298

  Fly   376 NGTF---------SDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGGGGGA 431
            .|:.         ||....::|:: ||.....|....::..|.|             |.|..||:
Human   299 EGSSQSESGSQRGSDKVSPENGLE-DVAIDLSSSARQETKKVHP-------------GAGAQGGS 349

  Fly   432 SSSLHCGLDG 441
            :|:   .|:|
Human   350 NST---ALEG 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	34/55 (62%)
VSX1	NP_055403.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		13/56 (23%)
		Octapeptide motif	31..38		2/6 (33%)
		PRK14959	<47..>149	CDD:184923	27/160 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..167		9/53 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	161..166		1/4 (25%)
		Homeodomain	165..221	CDD:459649	34/55 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..365		19/94 (20%)