Protein Alignment unc-4 and RAX

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_038463.2
• Gene: RAX / 30062
• HGNCID: 18662
• Length: 346
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 78/293 - (26%)
• Similarity: 106/293 - (36%)
• Gaps: 129/293 - (44%)

  Fly   209 GNRQSLPPAGPPSEG--------SNEDG------GFP-----GD---GDDDSSAAKRRRSRTNFN 251
            |:..|.|||..|:..        ..|.|      |.|     |:   .:::....|.||:||.|.
Human    80 GSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPKKKHRRNRTTFT 144

  Fly   252 SWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGPGRPAHNAQ 316
            ::||.||||||..|||||::.||.||.:::|.|.||.|||||||||.|::|
Human   145 TYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQE-------------- 195

  Fly   317 PQTCSGEPIPPNELKAKERARRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKANGTFSD 381
                                        .::..:.|||...:.                  :||.
Human   196 ----------------------------KLEVSSMKLQDSPLL------------------SFSR 214

  Fly   382 SDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGG------------GGGASSS 434
            |.                    .|..:||  ||.|.|.|||..||.            ||||::.
Human   215 SP--------------------PSATLSP--LGAGPGSGGGPAGGALPLESWLGPPLPGGGATAL 257

  Fly   435 LHCGLDGDGDSSRAGSFIGGGGSLGSPSSVAPP 467
            .  .|.|.|..:::           .|:|..||
Human   258 Q--SLPGFGPPAQS-----------LPASYTPP 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	35/55 (64%)
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..145		17/64 (27%)
		Homeodomain	137..193	CDD:459649	35/55 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..318		30/179 (17%)
		OAR	319..335	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333