DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment unc-4 and Uncx

DIOPT Version :9

Sequence 1:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_038730.1	Gene:	Uncx / 22255	MGIID:	108013	Length:	530	Species:	Mus musculus

Alignment Length:	391	Identity:	142/391 - (36%)
Similarity:	173/391 - (44%)	Gaps:	96/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PFLQFGVPGVFGPNGPFLGRP----RFDAASAGGHPNSAAAAAAATQMAAVNASNAFANLTGLSA 178
            |..|||     |..|..:|.|    ........||...:||||||.      ||..| ::.||.:
Mouse    10 PHAQFG-----GSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAAAA------ASVPF-SIDGLLS 62

  Fly   179 AALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAGPPSEGSNE-----DGGFPGDGDDDS 238
            .          :..||.||.|          |...|.||.....|.::     |.   ||.|.:|
Mouse    63 G----------SCAAAAASVV----------NPTPLLPAACGVAGESQPFKLADS---GDPDKES 104

  Fly   239 SAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREH 303
            ...||||:||||..|||||||:||:.|||||:|||||||:||||.||||.|||||||||.||:|:
Mouse   105 PGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKEN 169

  Fly   304 TKKGPGRPAHNAQPQTCSGEPIPPNELKAKE----RARRRKKLAKAIDRQARKLQAKGITVDLEA 364
            |||||||||||:.|.||||||:.|.|:..||    ..::||...|.:..|:|.|.:.|
Mouse   170 TKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQSRHLHSPG------- 227

  Fly   365 LKAEYISQHKANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGG-- 427
                .:|.|.|..:.|||            ||.....|............|.|..|.|..|..
Mouse   228 ----GLSLHSAPSSDSDS------------GGGGLSPEPPEPPPPTAAAKGPGAHGSGIAGSAPV 276

  Fly   428 -------------------GGGASSSLHCGLDGDGDSSRAGSFIGGGGSLGSP--SSVAPPSMLS 471
                               ..||.|....|...|.|:...|.  |...:.|.|  |..:..|:||
Mouse   277 PPGEPPAPGTCDPAFYPSQRSGAGSQPRLGRPADKDTVPCGP--GAAATAGLPKASPFSVESLLS 339

  Fly   472 N 472
            :
Mouse   340 D 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	42/52 (81%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	11/44 (25%)
Uncx	NP_038730.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111		7/23 (30%)
		Homeobox	112..165	CDD:278475	42/52 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..360		60/201 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7100
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004658
OrthoInspector	1	1.000	-	-		otm43154
orthoMCL	1	0.900	-	-		OOG6_108739
Panther	1	1.100	-	-	LDO	PTHR46799
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.000