Protein Alignment unc-4 and GSC

DIOPT Version :10

• Sequence 1: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_776248.1
• Gene: GSC / 145258
• HGNCID: 4612
• Length: 257
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 62/239 - (25%)
• Similarity: 85/239 - (35%)
• Gaps: 83/239 - (34%)

  Fly   126 GVFGPNGPFLGRPRFDAASAGGHPNSAAAAAAATQMAAVNASNAFANLTGLSAAALRNVSAAQTT 190
            |.....|.|..||    .:.||     |...||...:.:..:|.|.....:.||.   |..|...
Human    49 GASSDYGAFYPRP----VAPGG-----AGLPAAVSGSRLGYNNYFYGQLHVQAAP---VGPACCG 101

  Fly   191 AVAAVASTVATIQHRLMIGNRQSLPPAG---------PPSEGSNEDGGFPGDGD----------- 235
            ||                      ||.|         ||        |:.|.|.
Human   102 AV----------------------PPLGAQQCSCVPTPP--------GYEGPGSVLVSPVPHQML 136

  Fly   236 ----------------DDSSAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKE 284
                            :.....::||.||.|...|||.||..|..:.|||:..||.||.::.|:|
Human   137 PYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLRE 201

  Fly   285 SRVAVWFQNRRAKVRKREHTKKGPGRPAHNAQP--QTCSGEPIP 326
            .:|.|||:|||||.|::   |:.....:.||:.  :|.|.:..|
Human   202 EKVEVWFKNRRAKWRRQ---KRSSSEESENAEKWNKTSSSKASP 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	29/55 (53%)
GSC	NP_776248.1	Homeodomain	161..217	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..257		9/33 (27%)