DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment unc-4 and uncx

DIOPT Version :9

Sequence 1:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001305673.1	Gene:	uncx / 100492016	XenbaseID:	XB-GENE-920201	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	158/518 - (30%)
Similarity:	210/518 - (40%)	Gaps:	127/518 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PFLQFG--VPGVFGPNGPFLGRPRFDAASAGGHPNSAAAAAAATQMAAVNASNAFANLTGLSAAA 180
            |..|||  :.|:.|...|......::.||   |...:||||..                 .|...
Frog    10 PHAQFGGSMSGMVGFPYPLGHHHVYELAS---HQLQSAAAAVP-----------------FSIDG 54

  Fly   181 LRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAGPPSEGSNEDGGFPG--DGDDDSSAAKR 243
            |.|.|        ..||.:          |...|.|:|....|.::......  |.|.:|...||
Frog    55 LLNGS--------CTASVI----------NPTPLLPSGCGLNGDSQQYKLSDSIDPDKESPGCKR 101

  Fly   244 RRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVAVWFQNRRAKVRKREHTKKGP 308
            ||:||||..|||||||:||:.|||||:|||||||:||||.||||.|||||||||.||:|:|||||
Frog   102 RRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGP 166

  Fly   309 GRPAHNAQPQTCSGEPIPPNELKAKE---RARRRKKLAKAIDRQARKLQ---------------A 355
            ||||||:.|.||||||:.|.|:..||   ..::::|..|.:.|...:||               .
Frog   167 GRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKQEKKMLRNQNRLQHSPGDMSLHTPSSDSD 231

  Fly   356 KGITVDLEALKAEYISQHKANGTFSDSDLEDDGIQIDVVGGTDSDDEGDSDAVSPVRLGGGGGGG 420
            .|::.:|::...|  |.|...|. |.|..:....|..........:.|..|.||...........
Frog   232 SGLSQNLDSSSLE--SSHPDMGQ-SRSQTQASCDQTGQAFFQSQRNTGQRDRVSDKESPVEANHN 293

  Fly   421 GGTGGGGGGGASSSLH----------------CGLDGDGDSSRAGSFIGGGGSLGSPSS------ 463
            .|....|.|.|...|:                .|::..| .:...:.||.|..|..|.:
Frog   294 SGLCPNGRGAAFQKLNPFSVESLLSDSPPKRKTGIEFPG-LTNPRTLIGKGHFLLYPITQPLGFI 357

  Fly   464 VAPPSMLSNGAVQFGKLEPMDG------NESEERDRERDSPKPL--LFPAKAFHQLNLQSSQQHH 520
            |...|:.||.|.:.    |..|      |.:..:.....||...  |:|.|  |..:.||:.
Frog   358 VPQASIKSNSAQEL----PSPGIKDSLHNSNSGQPSLNTSPNSAQNLYPNK--HTNSTQSTT--- 413

  Fly   521 GLVVGQGQGSGSGHGHGHQHNHHQHHLHHGSASASAAAAVANLVHQTSPISMRRSNPFSIESL 583
             |.|.:.:...                |||:.|:|....       |..:....|.|.|.:||
Frog   414 -LTVCKTENGD----------------HHGATSSSGDTG-------TEQLDSTYSEPKSPKSL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	42/52 (81%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	11/58 (19%)
uncx	NP_001305673.1	homeobox domain	101..160		47/58 (81%)
uncx	NP_001305673.1	Homeobox	104..158	CDD:365835	42/53 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7033
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	157	1.000	Inparanoid score	I4175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004658
OrthoInspector	1	1.000	-	-		otm48289
Panther	1	1.100	-	-	LDO	PTHR46799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060