Protein Alignment raskol and SYNGAP1

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_047275406.1
• Gene: SYNGAP1 / 8831
• HGNCID: 11497
• Length: 1344
• Species: Homo sapiens
• Alignment Length: 1599
• Identity: 448/1599 - (28%)
• Similarity: 674/1599 - (42%)
• Gaps: 385/1599 - (24%)

  Fly   483 VHQGVMQGALSISCAGDNSSNNGSWGKHFYQPYD-------VCPLSLDELNCYFQADQCEKLICE 540
            :|:|.:. |:|.:...|....:....::.:.|||       .|.:|.::| .....|:...|:
Human     8 IHRGSIP-AMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQL-LMLDEDEIHPLL-- 68

  Fly   541 RFKIRDLAIHMASASAIGADLSVTTENETTATADDDAGHHSDTSYEKA-CRRGSAPTTPILGSKQ 604
               |||.....:....:...:||..|...          |.:..|... .||.|.|     |.||
Human    69 ---IRDRRSESSRNKLLRRTVSVPVEGRP----------HGEHEYHLGRSRRKSVP-----GGKQ 115

  Fly   605 HQTEHNATSRF---TNFFSKK-SNPLKRTKSVTKLERTK-----------------RGSGGLRGS 648
            :..|....:.|   ..|.|:: .:.:|||||..||:||.                 |.....:.|
Human   116 YSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKES 180

  Fly   649 RSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIY 713
            .|||||||..:....::|:......:.|||.|:||:..||:|... .|.:.::|.|..|||.||.
Human   181 HSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTS-SGTKCFACRSAAERDKWIE 244

  Fly   714 SLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQT---DLLFWG 775
            :|::::.||.:::||.||.||:|:.||:.|||||||:|||.||..||.||:.|.::   |.:|||
Human   245 NLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWG 309

  Fly   776 EHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPI-LSDKAGDS 839
            |||:|.::|.:..:.::::|:.|||:|:||..:||.|.:||..:..|...|||||: |...:|.|
Human   310 EHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGS 374

  Fly   840 LGRTSG-----GGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVI 899
            .|..||     |||||.|.|...|.:|:|.|:|:..|||:.:|..|..|:..:|:.:|..|||.:
Human   375 GGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPAL 439

  Fly   900 GVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLATKSMEAFLKLTGEQ 963
            .||.||::..|||.::.:.|.|..||:|:...::.|..: :.|.||.|:||||::|.:::|.|::
Human   440 NVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQK 504

  Fly   964 YLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLR 1028
            ||:|.:...|..|.:||.:|||||.|   .:|.||...||.||.....|...:..||..||.:|:
Human   505 YLKDAIGEFIRALYESEENCEVDPIK---CTASSLAEHQANLRMCCELALCKVVNSHCVFPRELK 566

  Fly  1029 NCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQ 1093
            ..||::|.|..:.||:|:||.|||||:|||||||||:|||||.:..|.|..:.:|.|||:||.:|
Human   567 EVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQ 631

  Fly  1094 TLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILD---WAGYIDQGKQLS 1155
            .||||::|..||:|:.|:|:|||.|...|||||..||..      |::.:   :.||||.|::||
Human   632 NLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNL------DTLTNSSSFEGYIDLGRELS 690

  Fly  1156 ILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENR 1220
            .||:||.|.|.:|.:....:|.||..:|::||        |||                     |
Human   691 TLHALLWEVLPQLSKEALLKLGPLPRLLNDIS--------TAL---------------------R 726

  Fly  1221 NPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNG 1285
            ||         |.::...:||:..:||..::..|.:..:|.|...|. :|::...|     ...|
Human   727 NP---------NIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLN-SSIDLQSF-----MARG 776

  Fly  1286 LLQQQQQQQQQQQQQQQQHQQLQQHG----HQQQP--HHQHPLQMLSNS------QTSIAGNQYM 1338
            |.......:.....:::........|    :..:|  ....|....|:|      |..::.|:.:
Human   777 LNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSV 841

  Fly  1339 S-------SPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTM 1396
            |       .|||..::.|.:::|      :..:|||..|........|.|   .||.:.|..|
Human   842 SMLDLQGDGPGGRLNSSSVSNLA------AVGDLLHSSQASLTAALGLRP---APAGRLSQGS-- 895

  Fly  1397 ERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQI 1461
                                                       |||                |..
Human   896 -------------------------------------------GSS----------------ITA 901

  Fly  1462 SGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLD 1526
            :|...|...|.....|..:..:..:......|....| |...||:..|....|
Human   902 AGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADG-PGPPGGHGGGGGHGP------------ 953

  Fly  1527 DLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQS 1591
                         |::||:|:. ..:|:|...|..........:||...|||.      |.|..:
Human   954 -------------PSSHHHHHH-HHHHRGGEPPGDTFAPFHGYSKSEDLSSGV------PKPPAA 998

  Fly  1592 SSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRS--SAQSNTHQQQQQQQQQQFGSRLKPIG 1654
            |         .:.||:....| .||     .|..:|.  |.|.|........|......|..|.|
Human   999 S---------ILHSHSYSDEF-GPS-----GTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSG 1048

  Fly  1655 -GGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSS 1718
             ||         .|||                         .:...|.|....|:..:|.....|
Human  1049 PGG---------GSGG-------------------------GSGGGGGGQPPPLQRGKSQQLTVS 1079

  Fly  1719 SSTSASASTSNLGKSGGSSAYGRL---NGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPH 1780
            ::.....|:.||.:|...| ||..   ...|.:|...| |.|||.|..|.||..|....|.|.|
Human  1080 AAQKPRPSSGNLLQSPEPS-YGPARPRQQSLSKEGSIG-GSGGSGGGGGGGLKPSITKQHSQTP- 1141

  Fly  1781 QQQQNPMQQQQQR--------------------ERDQ-EHKQYAGSVAGSVGSATSAAQRRLSLD 1824
             ...||.....:|                    ||:: :.|:|:                 .|:|
Human  1142 -STLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYS-----------------KSMD 1188

  Fly  1825 SARTLSDSSTDTEGHCNQLQE--GKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLD 1887
            .:|.  |...:.|...:.|:|  ....|:|..          .|:.|....:|..:|.:..|.
Human  1189 ESRL--DRVKEYEEEIHSLKERLHMSNRKLEE----------YERRLLSQEEQTSKILMQYQA-- 1239

  Fly  1888 TLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLITMEEELR 1952
                .|::.|..||....|                   .:|.::|||.       ||:.:|||||
Human  1240 ----RLEQSEKRLRQQQAE-------------------KDSQIKSIIG-------RLMLVEEELR 1274

  Fly  1953 REQLKMSLALSH-KQRVIEEQ-GQQIAALDAANSRLLSA 1989
            |:...|:..|.. |:|:::.| .:|:..|...|.|:..|
Human  1275 RDHPAMAEPLPEPKKRLLDAQVERQLPPLGPTNPRVTLA 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	43/134 (32%)
		C2_SynGAP_like	721..874	CDD:175980	75/161 (47%)
		RasGAP_DAB2IP	865..1192	CDD:213338	142/330 (43%)
		DUF3498	<1927..1997	CDD:463427	22/65 (34%)
SYNGAP1	XP_047275406.1	PH_SynGAP	122..313	CDD:270178	74/191 (39%)
		C2_SynGAP_like	252..414	CDD:175980	75/161 (47%)
		RasGAP_DAB2IP	405..728	CDD:213338	146/360 (41%)
		DUF3498	718..1317	CDD:463427	169/857 (20%)