Protein Alignment raskol and IRA2

DIOPT Version :9

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_014560.1
• Gene: IRA2 / 854073
• SGDID: S000005441
• Length: 3079
• Species: Saccharomyces cerevisiae
• Alignment Length: 1231
• Identity: 235/1231 - (19%)
• Similarity: 387/1231 - (31%)
• Gaps: 461/1231 - (37%)

  Fly   161 SGNNNSTTASPSKLKRYGIVLNVISLNGSDNEQSSLGSNGSSMPSMP-SMPNGQNIPNAAAPRTH 224
            :..::.|..||..|......:|.:||.||...::|  .|.:|:.|.| ::.:...:.:..|||..
Yeast   885 TSQSSMTPVSPLGLDTDICPMNTLSLVGSSTSRNS--DNVNSLNSSPKNLSSDPYLSHLVAPRAR 947

  Fly   225 ---------FNEENDIVLATPPPPKQQALSAAHESNDYDDDSEISRMQTN--TSTPIKLMKSRSR 278
                     ...:....|.:||..::              .|.:.|.||.  ::||:.:..|
Yeast   948 HALGGPSSIIRNKIPTTLTSPPGTEK--------------SSPVQRPQTESISATPMAITNS--- 995

  Fly   279 TNILAVPLPSVERGLATTNTTPNNNNINGNSNGSTSNTTTTTTTTTLITLRAKSKTL-------- 335
                 .||.|...|:.:..........:..|.|....:|.......||.......||
Yeast   996 -----TPLSSAAFGIRSPLQKIRTRRYSDESLGKFMKSTNNYIQEHLIPKDLNEATLQDARRIMI 1055

  Fly   336 ---------------PQNL-----------------------SPSVVLREAAA--LDELEKKREK 360
                           |.|:                       ||.|.|:..|.  :|.|......
Yeast  1056 NIFSIFKRPNSYFIIPHNINSNLQWVSQDFRNIMKPIFVAIVSPDVDLQNTAQSFMDTLLSNVIT 1120

  Fly   361 YQEKQEKRE----------------------KLQEKQRQLFGGSTA------SQIAGSSPYK--- 394
            |.|..|...                      |:..::||:....|.      |.:||.:...
Yeast  1121 YGESDENISIEGYHLLCSYTVTLFAMGLFDLKINNEKRQILLDITVKFMKVRSHLAGIAEASHHM 1185

  Fly   395 --LQNSCSATSILTHSFPPKNLF--LLKSTPKLSTDIAAATPPNTSAI----------------- 438
              :.:|...|..|......:.||  |..|..|:...:..|.....|||
Yeast  1186 EYISDSEKLTFPLIMGTVGRALFVSLYSSQQKIEKTLKIAYTEYLSAINFHERNIDDADKTWVHN 1250

  Fly   439 -------CS---PPKKSLSFIRRAHST------------------------KVARSNSLLKP--- 466
                   |.   ....|::|.||..:.                        ....|.||.|.
Yeast  1251 IEFVEAMCHDNYTTSGSIAFQRRTRNNILRFATIPNAILLDSMRMIYKKWHTYTHSKSLEKQERN 1315

  Fly   467 ---NQAGILGSGSGSNGLGVHQGVMQGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELN-- 526
               |.||||.|.||.  |.:::.::|                          ::.|..||.::
Yeast  1316 DFRNFAGILASLSGI--LFINKKILQ--------------------------EMYPYLLDTVSEL 1352

  Fly   527 ----CYFQADQCEKL----ICERFKIRDL---AIHMASASAIGADLSVTTENETTATADDDAGHH 580
                ..|.:.||:.|    :..|...||:   .:|..|.:.:..:|.:..:
Yeast  1353 KKNIDSFISKQCQWLNYPDLLTRENSRDILSVELHPLSFNLLFNNLRLKLK-------------- 1403

  Fly   581 SDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGL 645
                 |.||...|.|             .|.:|...            .:.:.|:.||..|
Yeast  1404 -----ELACSDLSIP-------------ENESSYVL------------LEQIIKMLRTILG---- 1434

  Fly   646 RGSRSHESLLSSHAVMSTIDLSCTGAVGVAPV--------------------HQSV-LGRRHCFQ 689
            |...::..:|.|..::..||| .|..:...|.                    |..| ||.::.|.
Yeast  1435 RDDDNYVMMLFSTEIVDLIDL-LTDEIKKIPAYCPKYLKAIIQMTKMFSALQHSEVNLGVKNHFH 1498

  Fly   690 VRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNL--PPKKRYFCE 752
            |:         :...||..|.:..|:.:.                   |:.:||  |.|:....:
Yeast  1499 VK---------NKWLRQITDWFQVSIARE-------------------YDFENLSKPLKEMDLVK 1535

  Fly   753 LQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPE------------------INVITVNVFREVDK 799
            ..:| .||..|:::..|.:.:...| .|.:||.                  .|::    .:.::|
Yeast  1536 RDMD-ILYIDTAIEASTAIAYLTRH-TFLEIPPAASDPELSRSRSVIFGFYFNIL----MKGLEK 1594

  Fly   800 KKKRDKYQFVGSVKIPV---HDVTSRLPCEQWYPILSDKAGDSLGRTSGG------------GGS 849
            ...||.|        ||   |.::          :|:|....||...|..            |.|
Yeast  1595 SSDRDNY--------PVFLRHKMS----------VLNDNVILSLTNLSNTNVDASLQFTLPMGYS 1641

  Fly   850 GSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQ----- 909
            |:::        |:..|..   :.||:..|:.||                  .||.|:|:
Yeast  1642 GNRN--------IRNAFLE---VFINIVTNYRTY------------------TAKTDLGKLEAAD 1677

  Fly   910 ---------------------ALVLLMHAQGLAGAF----LTDVVALDLLRVGDQRLT-----FR 944
                                 |..:..:|.||..||    .|.:|...|::...::.:     .|
Yeast  1678 KFLRYTIEHPQLSSFGAAVCPASDIDAYAAGLINAFETRNATHIVVAQLIKNEIEKSSRPTDILR 1742

  Fly   945 GNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAV 1009
            .||.||:|:....:..|.:||..||...:.::||:....|::..|...|.|   :||.......:
Yeast  1743 RNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFEIEKLKPEDSDA---ERQIELFVKYM 1804

  Fly  1010 RGAWQCIFESHKHFPAQL-RNCFATFRERLQQLGRQDMADNLISAS---IFLRFLCPAILSPSLF 1070
            ....:.|..|..:||..| ..|     :.:.::..:...|:.|.|:   :||||.|||::||...
Yeast  1805 NELLESISNSVSYFPPPLFYIC-----QNIYKVACEKFPDHAIIAAGSFVFLRFFCPALVSPDSE 1864

  Fly  1071 NITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEF-----LNDFLEQEAARMQQFL 1126
            ||. ::......|....:||.:|.:||     |.|||..:     ..|||::.:.|:.:||
Yeast  1865 NII-DISHLSEKRTFISLAKVIQNIAN-----GSENFSRWPALCSQKDFLKECSDRIFRFL 1919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	22/134 (16%)
		PH	<656..720	CDD:278594	16/84 (19%)
		C2_SynGAP_like	721..874	CDD:175980	32/187 (17%)
		RasGAP	856..1185	CDD:214617	75/315 (24%)
		RasGAP_DAB2IP	865..1192	CDD:213338	74/306 (24%)
IRA2	NP_014560.1	RasGAP_Neurofibromin_like	1672..1990	CDD:213341	64/262 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.970