DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and BUD2

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_012831.1	Gene:	BUD2 / 853770	SGDID:	S000001575	Length:	1104	Species:	Saccharomyces cerevisiae

Alignment Length:	1097	Identity:	228/1097 - (20%)
Similarity:	390/1097 - (35%)	Gaps:	340/1097 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 PTTPILGSKQ-HQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGLRGS-------RSH 651
            |.|.||.|.. ...:.|:...|:.....|||.:        |:...:..|.|..|       ||.
Yeast   187 PATNILESPDIINNDDNSVGWFSAMGVLKSNGM--------LDLLLQSDGSLIYSLNISQLLRSE 243

  Fly   652 ESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLG--------------------------------R 684
            ..:|.|..:.|...|    .:|..|:.:|.||                                .
Yeast   244 IRILDSSVLQSENSL----FLGELPLLRSQLGLEKFRIENIASAATNSSDISQEIIVEFPLRIDL 304

  Fly   685 RHCF-QVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAK----NLP 744
            ..|| .::...|.|.....||.:..|:                 :..||.|:.:.||.    ||.
Yeast   305 EDCFIALQSFARSEYLSITGSDKSNDM-----------------KISNSFKISILEANFQSINLN 352

  Fly   745 PKKRYFCELQLDKTLYG----RTSVKLQTDLLFWGEHFDFPDIPEINVITVNV---FREVDKKKK 802
            .|......:..|.|.:|    |||:...:...||.|.|.|.::..:....:.:   |.:::.||
Yeast   353 DKNNTPWSIFTDITAWGHTWARTSMVSNSSNPFWREEFQFNELLRLTNSYLEIKQLFHDLNNKK- 416

  Fly   803 RDKYQFVGSVKIP---VHDVTSRLPCEQWYPILS-DKAGDSLGRTSGGGGSGSKDKEQLPTLRIK 863
              :.:.:|.:||.   ::|  :|...|...||:. |.....:|                 |:.||
Yeast   417 --RLRLIGKIKITQEIIND--TRYNKETRLPIMDVDNKNFQIG-----------------TICIK 460

  Fly   864 CRFQSTDILPINVYGNFLTYLK---------------------ENYKRVCETLEPVIGVKAKEDI 907
            .......|||..   ||:...|                     ||..::.:|  .:|.:    ||
Yeast   461 ISSNLNFILPST---NFVKLEKLLMNANLSMVSNLIYKSSSSMENDNKLTQT--SIIFL----DI 516

  Fly   908 GQALVLL---MHAQGLAGAFLTD--VVALD--LLRVGDQRL--------TFRGNSLATKSMEAFL 957
            .|:|..:   .|.       |.|  :..:|  :.|:..:.|        .|||||:.|||:|.:.
Yeast   517 FQSLSRIEEWFHV-------LIDKELAKIDGTVSRINQKNLDSKHVFNSLFRGNSILTKSIEQYF 574

  Fly   958 KLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSS--------AGSLQRQQAALRGAVRGAWQ 1014
            ...|.:||...|||.:.|:|:|.:.||:||.:.....        |.:.:|    |...|...|:
Yeast   575 FRVGNEYLSKALSAILKEIIESNKSCELDPARVKEKDEVKKRKIIADNYKR----LYSWVTKIWK 635

  Fly  1015 CIFESHKHFPAQLRNCFATFRERLQQLGRQDMAD---NLISASIFLRFLCPAILSPSLFNITSEL 1076
            .::.:....|.::||....||::|:.:...|...   |.||..:||||.||.||:|.||...|:.
Yeast   636 RLYATSNDLPIEIRNVLKIFRQKLEIICIDDTLQIILNGISGLLFLRFFCPVILNPKLFKYVSQN 700

  Fly  1077 PSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSI 1141
            .:..|.|||||::|.|..|:..|:|..||.::..:|:|:::                .|   :.:
Yeast   701 LNETARRNLTLISKVLLNLSTLTQFANKEPWLMKMNNFIDK----------------RH---NDL 746

  Fly  1142 LDWAGYIDQGKQLSI--------LHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTAL 1198
            ||   |||:..|..:        |.|.:|.....:.:....:|..:.::||:
Yeast   747 LD---YIDKMTQKKLDFNSKILNLSSTISRPKLAIEQTMLDDLPQIPYLLDK------------- 795

  Fly  1199 PGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSE-QLLPQQSQLAQPQHAIVSKPLSAERGIM 1262
               .|..|...:.|.:.:||:.......:|..:..: :|:.::
Yeast   796 ---NLRETEFVNLIVNFSQEDMTKMEKYNHMDNGGKGELIEEE---------------------- 835

  Fly  1263 RGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSN 1327
             |:|:.:||.              |...::......:.:.:..:|:             .:.::.
Yeast   836 -GLLSGSSLN--------------LSVDKKDLDSPIEVKPEIGELE-------------FEKITE 872

  Fly  1328 SQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHG-------HQQHA------------ 1373
            :.|.|.|:..|:    |..:....|.:....||::|.:...       .::||
Yeast   873 NNTEIFGDDLMN----LLKSDDVGSRSRDLDNGANSGIKFNSIIPKAEEEKHAMKELEQESCLLY 933

  Fly  1374 ----HHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPN 1434
                |..::|..:.|       ||||:.. |:.....:||.....|.........:.|.:..|.|
Yeast   934 NRINHIRKRLSGYEC-------ASSTLFE-DKKYSISLSHKIFYEEIKEGKEIVLKLLNKPTNEN 990

  Fly  1435 ANG--------NVGSSNNNQSGSYDDMHGEF-QIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGR 1490
            ::.        .|.|.:||..|   |.:.:| .|.:|.         ::|....|:|:....:..
Yeast   991 SSARLQKFFTKGVSSKSNNTVG---DSYCKFLTIDVSD---------ENPKSSNKTSVHGTSSEN 1043

  Fly  1491 SHHKLNLGIPDHSGGYVRGNNLN-----------PNSNMPK--NLEDLDDLFKYAEE 1534
            ......|.:|:..|....||..:           ||:::||  |...|...||..:|
Yeast  1044 GAKDDYLTLPNSQGKGNLGNRFSPTKLSRIMRKPPNADVPKEQNSRKLTRWFKKKKE 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	26/153 (17%)
		PH	<656..720	CDD:278594	15/96 (16%)
		C2_SynGAP_like	721..874	CDD:175980	37/167 (22%)
		RasGAP	856..1185	CDD:214617	99/383 (26%)
		RasGAP_DAB2IP	865..1192	CDD:213338	97/381 (25%)
BUD2	NP_012831.1	C2	337..444	CDD:175973	26/111 (23%)
BUD2	NP_012831.1	RasGAP_CLA2_BUD2	460..819	CDD:213339	103/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm46640
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
TreeFam	0	0.000	Not matched by this tool.
	7	6.840