DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and RASAL1

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_001180449.1	Gene:	RASAL1 / 8437	HGNCID:	9873	Length:	806	Species:	Homo sapiens

Alignment Length:	641	Identity:	162/641 - (25%)
Similarity:	267/641 - (41%)	Gaps:	113/641 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   678 HQSVLGRRHCFQ--VRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKM----- 735
            |..::|:....:  :...|||           .|.||...|  :.|:||.......|::|
Human    80 HDDIIGKISLSREAITADPRG-----------IDSWINLSR--VDPDAEVQGEICLSVQMLEDGQ 131

  Fly   736 ------WVYEAKNLPPKKRYFCELQLDKTLYG----RTSVKLQTDLLFWGEHFDFPDIPEI-NVI 789
                  .|.:|::|.|:..........:..:|    .||...:|....|.|..:..::|.. :.:
Human   132 GRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPL 196

  Fly   790 TVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDK 854
            .|.:: :.|...|.|   |:|.|:.....:..: |.:.|:.:|.....:   ..|||
Human   197 RVELW-DWDMVGKND---FLGMVEFSPKTLQQK-PPKGWFRLLPFPRAE---EDSGG-------- 245

  Fly   855 EQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCE--TLEPVIGVK------AKEDIGQAL 911
             .|..||:|.|.....:||...|...:..|.|:.:...|  |..|:..::      .::|:...|
Human   246 -NLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKL 309

  Fly   912 VLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINEL 976
            |.|...:||||.||..:...::.|..|....||.||||:||||.|:||.|..||.:.|...|:.:
Human   310 VKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRV 374

  Fly   977 IQSERDCEVDPTKTS-G-----SSAGSLQRQQ------AALRGAVRGAWQCIFESHKHFPAQLRN 1029
            .:.::..|:||.|.. |     |..|:|..:|      ..|.|.:......|..|....|..:|.
Human   375 FEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRL 439

  Fly  1030 CFATFRERLQQL-----GRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVA 1089
            .|.....|:::.     .:||:....||..:||||..||||:|.||::..:....:.:|:|.|:|
Human   440 AFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLA 504

  Fly  1090 KTLQTLANFTR--FQGKENFMEFLNDFLEQEAARMQQFLE-IISTRPEHPA--------PDSILD 1143
            |.:|::.|..:  .||||.:|..|:.||.|..:|::.||: ::....:..|        |.|.:.
Human   505 KAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEEAGVPARALFPPSAIV 569

  Fly  1144 WAGYIDQGKQ----LSILHS-------LLSESL--AKLPEARQHELDPLQHI-----LDEISRAK 1190
            ..||:.:.|:    |:...:       |..|:|  :|.||.:.....|:.||     :||.:...
Human   570 REGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQL 634

  Fly  1191 EHGMGTALPGGYLPATSSTHS--IASENQENRNPGSSGSHAGSNSEQLLPQQSQLA 1244
            .|.|......|    |.:.|:  :..:|....|...|.....|     .|..::||
Human   635 PHVMQVVTQDG----TGALHTTYLQCKNVNELNQWLSALRKAS-----APNPNKLA 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	12/52 (23%)
		PH	<656..720	CDD:278594	9/43 (21%)
		C2_SynGAP_like	721..874	CDD:175980	35/168 (21%)
		RasGAP	856..1185	CDD:214617	110/382 (29%)
		RasGAP_DAB2IP	865..1192	CDD:213338	108/380 (28%)
RASAL1	NP_001180449.1	C2	6..126	CDD:301316	13/58 (22%)
		C2	134..255	CDD:301316	28/137 (20%)
		RasGAP	243..606	CDD:214617	107/371 (29%)
		RasGAP_RASAL	263..550	CDD:213337	88/286 (31%)
		PH-like	554..691	CDD:302622	30/137 (22%)
		PH	568..674	CDD:278594	24/114 (21%)
		BTK	683..710	CDD:279161
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870