DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and Dab2ip

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_001107596.1	Gene:	Dab2ip / 69601	MGIID:	1916851	Length:	1189	Species:	Mus musculus

Alignment Length:	1494	Identity:	414/1494 - (27%)
Similarity:	632/1494 - (42%)	Gaps:	461/1494 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 RRGSAPTTP-ILGSKQHQTEHNATS--RFTNFFSKK-SNPLKRTKSVTKLERTK---------RG 641
            |.||..:.| .:..|....|.:|::  |.|.|.|:: ...:|||||..||:|..         |.
Mouse    47 RPGSRRSLPGSMSEKNPSMEPSASTPFRVTGFLSRRLKGSIKRTKSQPKLDRNHSFRHILPGFRS 111

  Fly   642 SGG-------------LRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGG 693
            :..             |:.|||||||||..:.:..:|||....|.:.|||.|:||:.:||:|...
Mouse   112 AAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVIIKPVHSSILGQDYCFEVTTS 176

  Fly   694 PRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKT 758
             .|.:.:||.|..|||.|:.:||:::.||.:::||.::.||:||.|||:||.||:|.|||.||..
Mouse   177 -SGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDV 240

  Fly   759 LYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRL 823
            ||.||:.||:||.:||||||:|.::|.:..:||:::||.|||||:::..::|.|.:|...|..|.
Mouse   241 LYARTTSKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQ 305

  Fly   824 PCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENY 888
            ..|:|||:::.       ...||.|.|       |.:|||.|:|:..|||:.:|..|..::..:|
Mouse   306 FVEKWYPVVTP-------NPKGGKGPG-------PMIRIKARYQTVSILPMEMYKEFAEHITNHY 356

  Fly   889 KRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLATKS 952
            ..:|..|||::..|.||::..|||.::.:.|....||||::..::.|.|| :.|.||.|:||||:
Mouse   357 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKA 421

  Fly   953 MEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIF 1017
            :|.:|||.|::||||.|...|..|.:|:.:|||||:|   .|:..|...|..|:.....|:..|.
Mouse   422 IEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK---CSSADLPEHQGNLKMCCELAFCKII 483

  Fly  1018 ESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARAT 1082
            .|:..||.:|:..||::|:.....||.|:::.|||||:|||||||||:||||||:..|.|..|..
Mouse   484 NSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTA 548

  Fly  1083 RNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWA-- 1145
            |.|||:||..|.||||.:|..||.:|.|:|.|||.|...||:||..||.      |:::.:.|
Mouse   549 RTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN------PETLSNTAGF 607

  Fly  1146 -GYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPG-GYLPATSS 1208
             ||||.|::||.|||||.|::::|.::...:|.||..||.::..|      .:.|| |.||.|:.
Mouse   608 EGYIDLGRELSSLHSLLWEAVSQLDQSVVSKLGPLPRILRDVHTA------LSTPGSGQLPGTND 666

  Fly  1209 THSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEK 1273
            ..|         .|||..|...:..:::             ::...||......| :.:|....|
Mouse   667 LAS---------TPGSGSSSVSAGLQKM-------------VIENDLSGLIDFTR-LPSPTPENK 708

  Fly  1274 NIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYM 1338
            ::|                                                            ::
Mouse   709 DLF------------------------------------------------------------FV 713

  Fly  1339 SSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMN 1403
            :...|:|                                        |:|..|:|
Mouse   714 TRSSGVQ----------------------------------------PSPARSSS---------- 728

  Fly  1404 YPYMSHNGNDYETSTPSSTRS-------RTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQI 1461
              |...|..|.:.:..|.:.|       |||        :|..||
Mouse   729 --YSEANEPDLQMANGSKSLSMVDLQDARTL--------DGEAGS-------------------- 763

  Fly  1462 SGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLD 1526
                                   |.|            ||
Mouse   764 -----------------------PVG------------PD------------------------- 768

  Fly  1527 DLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLS---AKSSHCS-SGYQSI----- 1582
                       |.||:      ||           ||..:.|:   |:::..| :|..::
Mouse   769 -----------ALPAD------GQ-----------VPATQLLAGWPARAAPVSLAGLATVRRAVP 805

  Fly  1583 -STNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQF 1646
             .|.|..|: .:|...||.       |||:|:||.||:..
Mouse   806 TPTTPGTSE-GAPGRPQLL-------APLSFQNPVYQMAA------------------------- 837

  Fly  1647 GSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQR 1711
            |..|.|.|.|         :||....::..:.|:|:|..:|....|::.||...|....:| |:|
Mouse   838 GLPLSPRGLG---------DSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGEL-ARR 892

  Fly  1712 SLSGGSSSSTSASASTSNLGKSGGSSAYGRLN--GPLKRED------------------------ 1750
            .:|               |.:.||.....|.|  ||.:|.|
Mouse   893 QMS---------------LTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPTLLST 942

  Fly  1751 -VYGSGYGGSSGNVGYGLSTSSA--AGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGS 1812
             .|.....|:       |:::|.  ||......||..:......:.:....|||....|:.:...
Mouse   943 LQYPRPSSGT-------LASASPDWAGPGTRLRQQSSSSKGDSPELKPRAMHKQGPSPVSPNALD 1000

  Fly  1813 ATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNG 1877
            .|:|   .|...:|:.|.|....        .:...|.:||           |::.|.::   ..
Mouse  1001 RTAA---WLLTMNAQLLEDEGLG--------PDPPHRDRLR-----------SKEELSQA---EK 1040

  Fly  1878 EIQLLQQTLDTLCHTLDRDEA--ELRDSSDELFGLQRPAG-SNGSNNLSLQSES---TMRSIIDS 1936
            ::.:||..|......|:..|.  :.::.:.:...|:..|. ..|...|..|.|.   .|:.||.
Mouse  1041 DLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIIS- 1104

  Fly  1937 FFQSSCRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLSALTALRQRYETQ 2000
                  ||:::||||:::..:|..|:..||::|:.|.::||:|||||:||:||||.|::||..|
Mouse  1105 ------RLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQ 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	48/136 (35%)
		PH	<656..720	CDD:278594	24/63 (38%)
		C2_SynGAP_like	721..874	CDD:175980	67/152 (44%)
		RasGAP	856..1185	CDD:214617	144/332 (43%)
		RasGAP_DAB2IP	865..1192	CDD:213338	141/330 (43%)
Dab2ip	NP_001107596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		7/27 (26%)
		PH-like	75..261	CDD:302622	79/186 (42%)
		C2_SynGAP_like	203..342	CDD:175980	67/152 (44%)
		RasGAP	328..646	CDD:214617	141/326 (43%)
		RasGAP_DAB2IP	333..656	CDD:213338	141/337 (42%)
		DUF3498	646..1150	CDD:288827	151/857 (18%)
		Necessary for interaction with AKT1. /evidence=ECO:0000250	646..943		93/611 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..679		11/34 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..738		9/74 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..823		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..865		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..998		22/124 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1034		5/37 (14%)
		TBPIP	<1028..1116	CDD:284512	24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1163..1189		414/1494 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834580
Domainoid	1	1.000	123	1.000	Domainoid score	I5556
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm42791
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.830