Protein Alignment raskol and RASA2

DIOPT Version :9

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_016862457.1
• Gene: RASA2 / 5922
• HGNCID: 9872
• Length: 872
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 148/608 - (24%)
• Similarity: 245/608 - (40%)
• Gaps: 134/608 - (22%)

  Fly   621 KKSNPLKRTKSVTKLERTKRGSGGLRGSRSHES-------LLSSHAV---MSTIDLSCTGAVGVA 675
            ||.:.|.|.::..|.||.|        ::..||       .|..|.:   ..||:|.........
Human    43 KKKSKLCRRETSKKKERLK--------NKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQ 99

  Fly   676 PVHQSV---LGRRHCFQVRGGPRGERYYSC----GSRQERDLWI--YSLRK-------------S 718
            .|.:|:   ......|::   ||..:|.|.    .:..:|||.|  .:::|             |
Human   100 VVEKSLSPFFSEEFYFEI---PRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFS 161

  Fly   719 IAP---NAEHTRRTDNSLKM----------------WVYEAKNLPPKKRYFCELQLDKTLYG--- 761
            :.|   |:|...:....||:                .:.....||......|:.....:|.|
Human   162 LQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSR 226

  Fly   762 ----RTSVKLQTDLLFWGEHFDF------------------PDIPEINVITVNVFREVDKKKKRD 804
                :|.||.:|....:.|.|.|                  .||.::.:       .:|.....:
Human   227 NDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEI-------RIDLWNNGN 284

  Fly   805 KYQ--FVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQ 867
            ..|  |:|.:|:||:.:.:....:.|| :|..:          ..|:.|...:.|.:||:...:.
Human   285 LVQDVFLGEIKVPVNVLRTDSSHQAWY-LLQPR----------DNGNKSSKTDDLGSLRLNICYT 338

  Fly   868 STDILPINVYGNFLTYLKENYKRVCETLEPVIGVKA---------KEDIGQALV-LLMHAQGLAG 922
            ...:||...||...|.|.::     ..::|:....|         |.|....|| ||:|...|.
Human   339 EDYVLPSEYYGPLKTLLLKS-----PDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV- 397

  Fly   923 AFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDP 987
            .|.|.|..|||....|....||||||||:.::..:|:.|..||:.||...::|:..|.:.||:||
Human   398 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDP 462

  Fly   988 TKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQD--MADNL 1050
            .|.  ....:::..:..||..|...:..|.:|....|..:.:.|.:.|:...|....|  :..:.
Human   463 IKL--KEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSA 525

  Fly  1051 ISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANF-----TRFQGKENFM-E 1109
            :|:.:||||...|::||..|::....|.|:..|.|||::||:|||.::     ::...||.|| |
Human   526 VSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCE 590

  Fly  1110 FLNDFLEQ-EAARMQQFLEIIST 1131
            |...|.|: ....:::||:.||:
Human   591 FFKMFQEEGYIIAVKKFLDEISS 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	31/142 (22%)
		PH	<656..720	CDD:278594	17/88 (19%)
		C2_SynGAP_like	721..874	CDD:175980	35/198 (18%)
		RasGAP	856..1185	CDD:214617	89/295 (30%)
		RasGAP_DAB2IP	865..1192	CDD:213338	86/286 (30%)
RASA2	XP_016862457.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840