DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and RASA1

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_002881.1	Gene:	RASA1 / 5921	HGNCID:	9871	Length:	1047	Species:	Homo sapiens

Alignment Length:	631	Identity:	168/631 - (26%)
Similarity:	272/631 - (43%)	Gaps:	99/631 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 HNATSRFTN--FFS---KKSNPLKRTKSVTKLERTKRGSGGLRGSRSH----ESLLSSHAVMSTI 664
            :|...|.|.  |:.   ||...||:.|.    :|.|.....|.||.:.    ||...:......|
Human   460 YNTIRRKTKDAFYKNIVKKGYLLKKGKG----KRWKNLYFILEGSDAQLIYFESEKRATKPKGLI 520

  Fly   665 DLS-CTGAVGVAPVHQSVLGRRHCFQVRGGPRGER---YYSCGSRQER-DLWI------YSLRKS 718
            ||| |:    |..||.|:.||.:|||:......|.   :|..|...|: :.|:      .:||||
Human   521 DLSVCS----VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKS 581

  Fly   719 IAPNAEHTR-RTDNSLKMWVYEAKNLPPK--KRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDF 780
             :|...:.| |..:||.:.:.||..||.|  ...:|.:.|:.....:|..: :.....|.|.|.|
Human   582 -SPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVF 644

  Fly   781 PDI-PEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWY------PILSDKAGD 838
            .|: |:||...:.:..:..|.|..|    :..::..:..:......::|:      |:...:.|
Human   645 DDLPPDINRFEITLSNKTKKSKDPD----ILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG- 704

  Fly   839 SLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKA 903
                                :||::.|:....|:|...|..|...:.:....|...|..|
Human   705 --------------------SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHV----- 744

  Fly   904 KEDIGQALVLLMHAQGLAGAFLTD-VVALDLLRVGDQRLT--------FRGNSLATKSMEAFLKL 959
               .||...||  |..|...||.: :.:|.|..:.|:.::        ||..:||:..||.::|.
Human   745 ---CGQDRTLL--ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKA 804

  Fly   960 TGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFP 1024
            |..|::...|...|.::::|::.||:.|:|...:.  .:......|...:....:.||.:.:..|
Human   805 TATQFVHHALKDSILKIMESKQSCELSPSKLEKNE--DVNTNLTHLLNILSELVEKIFMASEILP 867

  Fly  1025 AQLRNCFATFRERLQQL--GRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTL 1087
            ..||..:...::.:|..  ....|...::|..:|||.:|||||:|.:|||.|:.||..|.|.|.|
Human   868 PTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLIL 932

  Fly  1088 VAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYIDQGK 1152
            |||::|.|||...|..||.:||.:|.|::....||..||:.:...||  .||:...  ...|..:
Human   933 VAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPE--LPDTTEH--SRTDLSR 993

  Fly  1153 QLSILHSLL---SESLAKLPE---ARQHELDPLQHILDEISRAKEH 1192
            .|:.||.:.   |:.|..|..   |:||.|..|..| .|:.:.|::
Human   994 DLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAI-TELLQQKQN 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	39/134 (29%)
		PH	<656..720	CDD:278594	23/74 (31%)
		C2_SynGAP_like	721..874	CDD:175980	31/162 (19%)
		RasGAP	856..1185	CDD:214617	100/345 (29%)
		RasGAP_DAB2IP	865..1192	CDD:213338	100/343 (29%)
RASA1	NP_002881.1	SH2_Nterm_RasGAP	161..264	CDD:198216
		SH3_RasGAP	281..339	CDD:212722
		SH2_Cterm_RasGAP	350..426	CDD:198217
		PH_RASA1	489..576	CDD:270080	26/90 (29%)
		C2_Ras_p21A1	591..716	CDD:176045	28/150 (19%)
		RasGAP_p120GAP	714..1045	CDD:213340	99/342 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820