Protein Alignment raskol and rasa1b

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_001921722.2
• Gene: rasa1b / 564822
• ZFINID: ZDB-GENE-090311-50
• Length: 1032
• Species: Danio rerio
• Alignment Length: 808
• Identity: 197/808 - (24%)
• Similarity: 324/808 - (40%)
• Gaps: 171/808 - (21%)

  Fly   484 HQGV--MQGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELNCYFQADQCEKLICERFKIRD 546
            |:|.  ..|.:|...|.:.....|..|....:|.|..|   .:.:.||:..:    ..:||||
Zfish   329 HEGKAWFHGKISKQEAYNLLMTVGQVGSFLVRPSDSTP---GDYSLYFRTTE----TIQRFKI-- 384

  Fly   547 LAIHMASASAIGADLSVTTENETTA------TADDDAGHHSDTSYEKACRR-----GSAPTTPIL 600
                           |.|..|:...      :.||...|:         ||     |.:....:
Zfish   385 ---------------SPTPSNQFMMGGRYYNSIDDIIEHY---------RREQIVEGHSLKDAL- 424

  Fly   601 GSKQHQTE-----------HNATSRFTN--FFS---KKSNPL------KRTKSVTKLERTKRGSG 643
             |.|||.:           :|...|.|.  |:.   ||...|      ||.|::..:
Zfish   425 -SVQHQEQVLTDIVEGKEIYNTIRRKTKDAFYKNIVKKGYILFNKGKGKRWKNLYFI-------- 480

  Fly   644 GLRGSRSH----ESLLSSHAVMSTIDLS-CTGAVGVAPVHQSVLGRRHCFQVRGGPRGER---YY 700
             |.|:.|.    ||...:......|||| |:    |..||.|:.||.:|||:......|.   :|
Zfish   481 -LEGNDSQLIYFESEKRATKPKGLIDLSVCS----VYEVHDSMFGRPNCFQIVVQHFSEEQCIFY 540

  Fly   701 SCGSRQER-DLWI-------YSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPK--KRYFCELQL 755
            ..|...|: :.|:       .:|||.:.|.:....|..:||.:.|.||..||.|  ...:|.:.|
Zfish   541 FAGETPEQAEDWMKCLQTFCNNLRKPVQPCSNKRLRQVSSLFLNVEEAHKLPSKHFTNAYCNIYL 605

  Fly   756 DKTLYGRTSVKLQTDLLFWGEHFDFPDI-PEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDV 819
            :.....:|..: :.....|.|.|.|.|: .|||...:::..:..|.|:.|    :..:..|:..:
Zfish   606 NSIQVAKTHPR-EGQNPVWTEEFIFDDLSSEINRFEISLSNKTKKSKEND----ILFMCCPLCRL 665

  Fly   820 TSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLP-TLRIKCRFQSTDILPINVYGNF--L 881
            ......::|:|:                .|....|..:| :||::.|:....|:|:.||...  |
Zfish   666 QRGQIIDEWFPL----------------SSHVPLKNVMPSSLRLRVRYSVEKIMPVEVYSELKEL 714

  Fly   882 TYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGN 946
            ..|::.:  |...|..|.|.| :..:...|:.:...|......|.::...::....:....||..
Zfish   715 VVLRDLH--VVSALAHVCGQK-RTLLASVLLRIFRHQNQEAQLLRELNDREICAEDEATTLFRAT 776

  Fly   947 SLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQ------AAL 1005
            :||:..||.::|.|...::...|...|.:::.|.:.||::|:|        |::.:      |.|
Zfish   777 TLASTLMEQYMKATATPFVHHALKDSILKIMDSRQSCELNPSK--------LEKNEDVNVNLAHL 833

  Fly  1006 RGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQD--MADNLISASIFLRFLCPAILSPS 1068
            ...|....:.||.:.:..|..||..:...::.::|...::  |...::|..:|||.:||||::|.
Zfish   834 LSIVSELLEKIFMAAEILPPTLRFIYGCLQKAVEQKWPRNTTMRTRVVSGFVFLRLICPAIVNPR 898

  Fly  1069 LFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRP 1133
            :|||.::.||..|:|.||||||.:|.|||...|..||.:||.:|.|::....||..||:.:....
Zfish   899 IFNIIADPPSPVASRTLTLVAKAVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMILFLDELGKVS 963

  Fly  1134 EHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTAL 1198
            |.|.|....:    .|..:.|:.||.|....|.:| ....::....||:|.::....|
Zfish   964 ELPEPTEHFN----TDVARDLAALHQLCVTHLDEL-RTLSNDRGAQQHVLKKLLAVSE------- 1016

  Fly  1199 PGGYLPATSSTHSIASENQENRNPGSSG 1226
               .|..|...:|           ||||
Zfish  1017 ---LLQQTQGQYS-----------GSSG 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	36/140 (26%)
		C2_SynGAP_like	721..874	CDD:175980	34/156 (22%)
		RasGAP_DAB2IP	865..1192	CDD:213338	91/336 (27%)
		DUF3498	<1927..1997	CDD:463427
rasa1b	XP_001921722.2	SH2	148..247	CDD:472789
		SH3_RasGAP	264..322	CDD:212722
		SH2_Cterm_RasGAP	334..409	CDD:198217	19/98 (19%)
		PH_RASA1	456..560	CDD:270080	30/116 (26%)
		C2_Ras_p21A1	576..701	CDD:176045	32/145 (22%)
		RasGAP_p120GAP	700..1029	CDD:213340	95/365 (26%)