DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and rasa1b

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_001921722.2	Gene:	rasa1b / 564822	ZFINID:	ZDB-GENE-090311-50	Length:	1032	Species:	Danio rerio

Alignment Length:	808	Identity:	197/808 - (24%)
Similarity:	324/808 - (40%)	Gaps:	171/808 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 HQGV--MQGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELNCYFQADQCEKLICERFKIRD 546
            |:|.  ..|.:|...|.:.....|..|....:|.|..|   .:.:.||:..:    ..:||||
Zfish   329 HEGKAWFHGKISKQEAYNLLMTVGQVGSFLVRPSDSTP---GDYSLYFRTTE----TIQRFKI-- 384

  Fly   547 LAIHMASASAIGADLSVTTENETTA------TADDDAGHHSDTSYEKACRR-----GSAPTTPIL 600
                           |.|..|:...      :.||...|:         ||     |.:....:
Zfish   385 ---------------SPTPSNQFMMGGRYYNSIDDIIEHY---------RREQIVEGHSLKDAL- 424

  Fly   601 GSKQHQTE-----------HNATSRFTN--FFS---KKSNPL------KRTKSVTKLERTKRGSG 643
             |.|||.:           :|...|.|.  |:.   ||...|      ||.|::..:
Zfish   425 -SVQHQEQVLTDIVEGKEIYNTIRRKTKDAFYKNIVKKGYILFNKGKGKRWKNLYFI-------- 480

  Fly   644 GLRGSRSH----ESLLSSHAVMSTIDLS-CTGAVGVAPVHQSVLGRRHCFQVRGGPRGER---YY 700
             |.|:.|.    ||...:......|||| |:    |..||.|:.||.:|||:......|.   :|
Zfish   481 -LEGNDSQLIYFESEKRATKPKGLIDLSVCS----VYEVHDSMFGRPNCFQIVVQHFSEEQCIFY 540

  Fly   701 SCGSRQER-DLWI-------YSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPK--KRYFCELQL 755
            ..|...|: :.|:       .:|||.:.|.:....|..:||.:.|.||..||.|  ...:|.:.|
Zfish   541 FAGETPEQAEDWMKCLQTFCNNLRKPVQPCSNKRLRQVSSLFLNVEEAHKLPSKHFTNAYCNIYL 605

  Fly   756 DKTLYGRTSVKLQTDLLFWGEHFDFPDI-PEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDV 819
            :.....:|..: :.....|.|.|.|.|: .|||...:::..:..|.|:.|    :..:..|:..:
Zfish   606 NSIQVAKTHPR-EGQNPVWTEEFIFDDLSSEINRFEISLSNKTKKSKEND----ILFMCCPLCRL 665

  Fly   820 TSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLP-TLRIKCRFQSTDILPINVYGNF--L 881
            ......::|:|:                .|....|..:| :||::.|:....|:|:.||...  |
Zfish   666 QRGQIIDEWFPL----------------SSHVPLKNVMPSSLRLRVRYSVEKIMPVEVYSELKEL 714

  Fly   882 TYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGN 946
            ..|::.:  |...|..|.|.| :..:...|:.:...|......|.::...::....:....||..
Zfish   715 VVLRDLH--VVSALAHVCGQK-RTLLASVLLRIFRHQNQEAQLLRELNDREICAEDEATTLFRAT 776

  Fly   947 SLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQ------AAL 1005
            :||:..||.::|.|...::...|...|.:::.|.:.||::|:|        |::.:      |.|
Zfish   777 TLASTLMEQYMKATATPFVHHALKDSILKIMDSRQSCELNPSK--------LEKNEDVNVNLAHL 833

  Fly  1006 RGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQD--MADNLISASIFLRFLCPAILSPS 1068
            ...|....:.||.:.:..|..||..:...::.::|...::  |...::|..:|||.:||||::|.
Zfish   834 LSIVSELLEKIFMAAEILPPTLRFIYGCLQKAVEQKWPRNTTMRTRVVSGFVFLRLICPAIVNPR 898

  Fly  1069 LFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRP 1133
            :|||.::.||..|:|.||||||.:|.|||...|..||.:||.:|.|::....||..||:.:....
Zfish   899 IFNIIADPPSPVASRTLTLVAKAVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMILFLDELGKVS 963

  Fly  1134 EHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTAL 1198
            |.|.|....:    .|..:.|:.||.|....|.:| ....::....||:|.::....|
Zfish   964 ELPEPTEHFN----TDVARDLAALHQLCVTHLDEL-RTLSNDRGAQQHVLKKLLAVSE------- 1016

  Fly  1199 PGGYLPATSSTHSIASENQENRNPGSSG 1226
               .|..|...:|           ||||
Zfish  1017 ---LLQQTQGQYS-----------GSSG 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	36/140 (26%)
		PH	<656..720	CDD:278594	22/75 (29%)
		C2_SynGAP_like	721..874	CDD:175980	34/156 (22%)
		RasGAP	856..1185	CDD:214617	94/339 (28%)
		RasGAP_DAB2IP	865..1192	CDD:213338	91/336 (27%)
rasa1b	XP_001921722.2	SH2	148..247	CDD:301589
		SH3_RasGAP	264..322	CDD:212722
		SH2_Cterm_RasGAP	334..409	CDD:198217	19/98 (19%)
		PH_RASA1	456..560	CDD:270080	30/116 (26%)
		PH	458..557	CDD:278594	30/111 (27%)
		C2_Ras_p21A1	576..701	CDD:176045	32/145 (22%)
		RasGAP	683..1026	CDD:214617	98/368 (27%)
		RasGAP_p120GAP	700..1029	CDD:213340	95/365 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820