DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and dab2ipb

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_005171937.1	Gene:	dab2ipb / 558237	ZFINID:	ZDB-GENE-030131-2449	Length:	1180	Species:	Danio rerio

Alignment Length:	1507	Identity:	426/1507 - (28%)
Similarity:	622/1507 - (41%)	Gaps:	477/1507 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 HHSDTSYEKACRR----GSAP--TTPILGSKQHQTEHNATS-----RFTNFFSKK-SNPLKRTKS 631
            ::.|:..|:..||    ||||  ..|.:       |..|.:     |.|.|.|:: ...:|||||
Zfish    39 NNKDSPPERTGRRRSIPGSAPDKVPPTM-------EPTAAAAATPFRVTGFLSRRLKGSIKRTKS 96

  Fly   632 VTKLERTKRGSGGLRG-----------------SRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQ 679
            ..||:|.......|.|                 |||||||||..:.:..:|||....|.:.|||.
Zfish    97 QPKLDRNSSFRHILPGFRPVDNERSHLMPRLKESRSHESLLSPTSAVEALDLSMEEEVLIKPVHS 161

  Fly   680 SVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLP 744
            |:||:.:||:| ....|.:.:||.|..|||.|:.:||::|.||.:::||.:|.|::|:.|||:||
Zfish   162 SILGQDYCFEV-STSTGSKCFSCRSAAERDKWMENLRRAIHPNKDNSRRVENMLRLWIIEAKDLP 225

  Fly   745 PKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFV 809
            .||:|||||.||.:||.||:.|::||.:||||||:|.::|.:..|||:|:|:.|||||:||..:|
Zfish   226 AKKKYFCELCLDDSLYARTTCKMKTDNVFWGEHFEFNNLPAVQSITVHVYRDSDKKKKKDKNNYV 290

  Fly   810 GSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPI 874
            |.|.|||..||||...|:|||:.....|.  |:.:|            |.:|||.|:||.:|||:
Zfish   291 GLVSIPVVTVTSRQLVEKWYPVSQPNPGK--GKAAG------------PMVRIKARYQSMNILPM 341

  Fly   875 NVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD- 938
            .:|..|..|...||..:|..|||||.||.||::..|||.::.:.|.|..||||::..::.|.|:
Zfish   342 ELYKEFAEYTTNNYMLLCSVLEPVISVKNKEEMACALVHILQSTGKAKDFLTDLMMSEVDRCGEN 406

  Fly   939 QRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQA 1003
            :.|.||.|:|.||::|.:|||.|::||||.|...|..|.:|:.:|||||:|.|.|   .|...|:
Zfish   407 EHLIFRENTLGTKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSSS---DLPEHQS 468

  Fly  1004 ALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPS 1068
            .||.....|:..|.||::.||.:|:..||::|:.....||.|:::.|||||:|||||||||:|||
Zfish   469 NLRMCCELAFCKIIESYRVFPRELKEVFASWRQECGNRGRPDISERLISASLFLRFLCPAIMSPS 533

  Fly  1069 LFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRP 1133
            |||:|.|.|..|..|.|||:||..|.|||||:|..||.:|.|:|.|||||...||:||..||.
Zfish   534 LFNLTQEYPDDRTARTLTLIAKVTQNLANFTKFGNKEEYMSFMNQFLEQEWTNMQRFLLEISN-- 596

  Fly  1134 EHPAPDSILDWA---GYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMG 1195
                |::|.:.|   ||||.|::||.|||||:|.|:::.::...:|.||..||.::     ||..
Zfish   597 ----PETISNTAGFEGYIDLGRELSTLHSLLAEVLSQMDQSAASKLGPLPRILRDV-----HGAL 652

  Fly  1196 TALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERG 1260
            |                        ||
Zfish   653 T------------------------NP-------------------------------------- 655

  Fly  1261 IMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQML 1325

Zfish   656 ----------------------------------------------------------------- 655

  Fly  1326 SNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQT 1390
            :|.|.|:..::..|                                             ||.|..
Zfish   656 TNVQMSVPSDRVPS---------------------------------------------PPVPGC 675

  Fly  1391 SASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHG 1455
            |.|:.:::|             ..::..|.......||
Zfish   676 SISTGIQKM-------------AIDSDLPGPVDFTRLP--------------------------- 700

  Fly  1456 EFQIQISGFDTSSAFVCKSPTPMMKS------SLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLN- 1513
                              ||||..|.      |.|..|:           |..|..|...|...
Zfish   701 ------------------SPTPENKDLFFVTRSSGLQGS-----------PTRSSSYSEANEPEL 736

  Fly  1514 --PNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKP--AAVPGKEQLSAKSSH 1574
              .|.....::.||.:..:..|  .::.||...:...|    :|.:.|  |..|........:.|
Zfish   737 GLANGGKSLSMVDLQEAARALE--PISIPAGITSEGMG----EGAMVPWNARTPQGNIAGGPTLH 795

  Fly  1575 CSSGYQSISTNPSPSQSSSPVE-SQLKAAMGSHNAPLAFKNPSYQLQ-----PQTGSSRSSAQSN 1633
                 :.:.:..:|....:|.. :||.       |||:|:||.||:.     ...|::...:.|.
Zfish   796 -----RPVQSPTTPGAEGAPGRPTQLL-------APLSFQNPVYQMAAGLPVSARGNASGDSGSE 848

  Fly  1634 THQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGAL--EAATLTPSSSDEQLSA-----DNYF 1691
            .|.........:     :.:||    .:..||..|.::  |.|..:...|..|||.     .|..
Zfish   849 CHSSVSSHSNNE-----ECLGG----TKTTFLTQGASVGEEFARRSGDFSRRQLSLTDPQHGNQP 904

  Fly  1692 SYAAAAAAGAGIATKLEAQRSLSGGSSSSTSA--SASTSNLGKSGGSSAYGR-LNGPLKREDVYG 1753
            :....::||        .||.:......:.:|  ..:..||..||   .|.| ||..:.......
Zfish   905 TVPRQSSAG--------PQRRIDQPPPPTQTAPRGRTPPNLLNSG---PYPRPLNNTMMSSSPDW 958

  Fly  1754 SGYGG-----SSGNVGYGLSTSSAAGHHQHPHQQQQNP------------------MQQQQQRE- 1794
            .|.|.     ||.:.|     .|....|:.||:|..:|                  ::|:.:.|
Zfish   959 PGSGARLRQQSSSSKG-----DSPETKHRAPHKQAPSPVNPSALDRTAAWLMNVPYIEQEPETEL 1018

  Fly  1795 -RDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGS 1858
             || ||.|     |....:..|..|.||.: |.:.|.:.....:|...|.|:.....|.|
Zfish  1019 CRD-EHTQ-----AEKYQAEISMLQDRLRM-SVQRLEEYEARLKGQEEQAQKMLLEYQAR----- 1071

  Fly  1859 GGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLS 1923
                                              ||..|..||...::
Zfish  1072 ----------------------------------LDESEERLRRQQED----------------- 1085

  Fly  1924 LQSESTMRSIIDSFFQSSCRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLS 1988
              .:..|:.||.       ||:::||||:::...|...:..||::|:.|.::||:|||||:||:|
Zfish  1086 --KDLQMKGIIS-------RLMSVEEELKKDHADMQAVVDSKQKIIDAQEKRIASLDAANARLMS 1141

  Fly  1989 ALTALRQRYETQ 2000
            ||:.|::||..|
Zfish  1142 ALSQLKERYSMQ 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	49/131 (37%)
		PH	<656..720	CDD:278594	24/63 (38%)
		C2_SynGAP_like	721..874	CDD:175980	74/152 (49%)
		RasGAP	856..1185	CDD:214617	156/332 (47%)
		RasGAP_DAB2IP	865..1192	CDD:213338	152/330 (46%)
dab2ipb	XP_005171937.1	PH-like	79..260	CDD:302622	79/181 (44%)
		C2_SynGAP_like	202..341	CDD:175980	74/152 (49%)
		RasGAP	328..656	CDD:214617	160/468 (34%)
		RasGAP_DAB2IP	332..655	CDD:213338	155/360 (43%)
		DUF3498	645..1141	CDD:288827	141/856 (16%)
		SPEC	<1017..1151	CDD:295325	51/205 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577555
Domainoid	1	1.000	133	1.000	Domainoid score	I5006
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1093
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm24616
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830