Protein Alignment raskol and RasGAP1

DIOPT Version :9

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Alignment Length: 1139
• Identity: 244/1139 - (21%)
• Similarity: 407/1139 - (35%)
• Gaps: 334/1139 - (29%)

  Fly   507 WGKHFYQ--PYDVCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENET 569
            |.:...|  |.....:..:||:.|...|..       |.:|.:.........:..:::.|...:|
  Fly   118 WDRDMKQDKPIGKIAIKREELHMYNHKDHW-------FSLRPVDQDSEVQGMVNVEVAFTEAQQT 175

  Fly   570 TATADD-DAG-----HHSDT---SYEKACRRGSAPTTPILGSKQHQTEHNATS---------RFT 616
            .:.::. |.|     ||.:.   |:::............|.:.|..:...|:|         |..
  Fly   176 QSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAA 240

  Fly   617 NFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLS-SHAVMSTIDL-----SCTGAVGVA 675
            ..|....:|..:|:....:..|...|..|...:||...:. :..|.:.:||     :|...| |.
  Fly   241 GLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFV-VC 304

  Fly   676 PVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEA 740
            ..|.|   .:|  ||                                   ||||..       ..
  Fly   305 TAHYS---NKH--QV-----------------------------------TRRTKQ-------RK 322

  Fly   741 KNLPP---KKRYFCELQLD-------KTLYGRTSVKLQTDLLFWGEHFD-FP----DIPEINVIT 790
            |.:.|   :..|| :|.:|       .|...:::..|::..   .:.:. :|    |:.|   |.
  Fly   323 KTVDPEFDEAMYF-DLHIDADAGSTNTTGSNKSAGSLESSA---NKGYSIYPVGGADLVE---IV 380

  Fly   791 VNVFREVDKKKKRDKYQFVGSVKIPVHDVTSR--LPCEQWY---PILSDKAGDSLGRT----SGG 846
            |:|:.:...... ||. |:|.|::|:.:...:  :....||   |.....:..||..|    :..
  Fly   381 VSVWHDAHGAMS-DKV-FLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATP 443

  Fly   847 GGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKE--NYKRVCETLEPVIG--VKAKEDI 907
            .|:.......:.:||:...:.:..:.|:..|.:.:..|.|  :.:.:..:...::|  |..|.::
  Fly   444 PGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEV 508

  Fly   908 GQALV-LLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSA 971
            .|.|| |..|.:.:| ..:..:...::..:.|....||||:|.:|.|:..::|:|..||..||..
  Fly   509 AQPLVRLFTHTERIA-PIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRP 572

  Fly   972 PINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRE 1036
            .:::::..::.||:||:|....||  :......|:..|...::.|.:|....|..|...|...||
  Fly   573 VLSQIVAEKKPCEIDPSKIKDRSA--VDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRE 635

  Fly  1037 RLQQ--LGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFT 1099
            ...:  ...:::..:::|..|||||..||||.|.||::|:|...|:.:|.|||::||:|:|.|..
  Fly   636 CAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLV 700

  Fly  1100 RFQG-----KENF-MEFLNDF-LEQEAARMQQFLEIISTRPE-----HPAP------DSILDWAG 1146
            ..:.     ||.| :|....| .||....::.|||:|||...     |||.      :.:|...|
  Fly   701 SSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEG 765

  Fly  1147 YIDQ--------GKQLSILHSLL---SESLAKLPEARQHELD-PLQHI----------------- 1182
            .:.:        |:|....|..|   |.|.|| .:.:|...| |||.|
  Fly   766 LMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAK-SKGKQPICDIPLQEIASVEQLKDKSFKMQNCF 829

  Fly  1183 -------------------------LDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNP 1222
                                     |.:|.......|....|..::   |..:|....:.|| :|
  Fly   830 KIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFV---SGFYSCCGRSDEN-SP 890

  Fly  1223 GSSGSHAGSNSEQLLPQ-----QSQLA---------QPQHAIVSKPLSAERGIMRGVLTPNSLEK 1273
            |         .:::|.:     |..|.         |..|.::...:|....::..:....||.:
  Fly   891 G---------CKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQ 946

  Fly  1274 NIFRYNDPTV------------------------------------------------------- 1283
            ...:.::|.|
  Fly   947 TQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPI 1011

  Fly  1284 -----------NGLLQQQ--QQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGN 1335
                       .|.|.||  ||||.||||||||.|||||  .|.||    .|..:.|.:.
  Fly  1012 GDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQ--FQPQP----VLPQMQNVRA----- 1065

  Fly  1336 QYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHG----------HQQHAHHPQQLHPHHCPPAPQT 1390
             |...|            |:|::|   :..||.          |||...|.|||........|..
  Fly  1066 -YPYQP------------ATSNMN---AYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLR 1114

  Fly  1391 SASSTMERMDRMNYPYMSHNGNDYETSTPSSTRS 1424
            |     .::.|.|....::|..:..:|:||||.|
  Fly  1115 S-----HQLQRHNNNLNNNNCGNGSSSSPSSTTS 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	21/119 (18%)
		PH	<656..720	CDD:278594	11/69 (16%)
		C2_SynGAP_like	721..874	CDD:175980	33/176 (19%)
		RasGAP	856..1185	CDD:214617	103/407 (25%)
		RasGAP_DAB2IP	865..1192	CDD:213338	102/405 (25%)
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	9/57 (16%)
		C2B_RasA3	280..462	CDD:175977	44/238 (18%)
		RasGAP	449..797	CDD:214617	94/350 (27%)
		RasGAP_GAP1_like	473..740	CDD:213330	79/269 (29%)
		PH	761..859	CDD:278594	17/98 (17%)
		PH_GAP1-like	763..867	CDD:269950	17/104 (16%)
		BTK	862..897	CDD:128417	8/47 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46640
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940