DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment raskol and vap

DIOPT Version :10

Sequence 1:NP_001285388.1 Gene:raskol / 32754 FlyBaseID:FBgn0261570 Length:2016 Species:Drosophila melanogaster
Sequence 2:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster


Alignment Length:571 Identity:153/571 - (26%)
Similarity:242/571 - (42%) Gaps:119/571 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   664 IDLSCTGAVGVAPVHQSVLGRRHCFQV--RGGP-RGERYYSCGSRQERDL-WIYSLRK------S 718
            |||||   ..:...|.|:..|.:|||:  |..| .....|.|...||..: ||.||:.      |
  Fly   428 IDLSC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLS 489

  Fly   719 IAPNAEHTRRTDNSLKMWVYEAKNLPPK--KRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFP 781
            .|.......|....|.:.|.||..||.|  ...:|.:.|::...|:|.||:..:.: |.|.|...
  Fly   490 RAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-WEEEFVLD 553

  Fly   782 DI-PEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSG 845
            |: |::..:|:.:.    .:.||.|...|..:.|.:..:.:....|.||.:        .|.|..
  Fly   554 DVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL--------TGMTPM 606

  Fly   846 GGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDI--G 908
            |         :..:||::.|:....|:|                  ||...|:..:..:.::  .
  Fly   607 G---------EWGSLRLRMRYLDDLIMP------------------CEEYSPLQQLLLESELYAV 644

  Fly   909 QALVLLMHAQ--GLAGAFL---------TDVVAL----DLLRVGDQRLTFRGNSLATKSMEAFLK 958
            :||..|.|..  .||.|.|         |:::.:    ::.|..:....|||.||||..|:.:::
  Fly   645 KALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMR 709

  Fly   959 LTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHF 1023
            .....:||..:|..:..:::|::..|::|||...:.......:  .|...:....|.||.|....
  Fly   710 TECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAE--FLLQILDLVTQSIFTSPDAC 772

  Fly  1024 PAQLR---NCFATF------RERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSA 1079
            |..:|   :|....      .|||       :...::|..||||.||||:|:|..|.:.||.|..
  Fly   773 PRNVRFICSCLQKAVMAKWPTERL-------VRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPM 830

  Fly  1080 RATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIIST--RPEHPAPDSIL 1142
            .|||:|.:|||.||.|||...|.|||.:||.:|.|:.:...||..||:.:|:  .|..|.     
  Fly   831 AATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPL----- 890

  Fly  1143 DWAGYIDQ---------GKQLSILHSL-LSESLAKLPEARQHELDPLQHIL 1183
              ..:::|         |::|:.||.: :|.|         .||..|.:||
  Fly   891 --GMFVEQSTNLNSQDTGRELATLHHICVSHS---------QELHELSNIL 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
raskolNP_001285388.1 PH_RasSynGAP-like 615..729 CDD:270082 23/74 (31%)
C2_SynGAP_like 721..874 CDD:175980 35/155 (23%)
RasGAP_DAB2IP 865..1192 CDD:213338 97/357 (27%)
DUF3498 <1927..1997 CDD:463427
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 21/58 (36%)
C2_Ras_p21A1 499..622 CDD:176045 34/144 (24%)
RasGAP 620..954 CDD:470620 96/354 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.