Protein Alignment raskol and Rasal3

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_001401865.1
• Gene: Rasal3 / 314596
• RGDID: 1309019
• Length: 1038
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 267/922 - (28%)
• Similarity: 392/922 - (42%)
• Gaps: 142/922 - (15%)

  Fly   581 SDTSYEKACRRGSAPT-TP------ILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERT 638
            |::|.:.|......|. ||      ..||.|   .||...     ..|:....||.||.......
  Rat   187 SESSMQAALGNLKDPVRTPGKIEPEATGSNQ---VHNVRK-----LLKRLKEKKRAKSELGAHTP 243

  Fly   639 KRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCG 703
            :.|.....|||  |||    |.:|.:||.....|.|.|:|.|:||..:||||... .|.|.:||.
  Rat   244 RDGPSSALGSR--ESL----ATLSELDLGVERDVRVWPLHPSLLGEPYCFQVTWA-GGSRCFSCR 301

  Fly   704 SRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLP----PKKRYFCELQLDKTLYGRTS 764
            |..|||.||..||:...|:.::..|.:..|.:||:|||.||    |..|  .||.||..|..||:
  Rat   302 SSAERDRWIEDLRRQFQPSQDNVERQETWLTVWVHEAKGLPRAAAPGVR--AELWLDGALLARTA 364

  Fly   765 VKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVT-SRLPC--- 825
            .:...|.|||.|.|.|..:|....:::.:      :........||.|.:.:.:|: .|.|.
  Rat   365 PRAGPDQLFWAERFHFEALPPARRLSLRL------RGAGPAGATVGRVVLELDEVSIPRAPAAGL 423

  Fly   826 EQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKR 890
            |:|:|:|...||                    ..||.:.|.:...:||...|.....:|..:|.|
  Rat   424 ERWFPVLGAPAG--------------------AVLRARIRVRCLRVLPSERYKELAEFLTFHYAR 468

  Fly   891 VCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLATKSME 954
            :|..|||.:..:|||::..|:|.::.|.|.|.|.:||:...:|.|.|. :.|.||.|:||||:::
  Rat   469 LCMALEPALSAQAKEELAAAMVRVLRATGRAQALVTDLGTAELERCGGREALLFRENTLATKAID 533

  Fly   955 AFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFES 1019
            .::||..::|||:||...:..|..|..||||||:|   .....|.:.||.||.:....::.|..|
  Rat   534 EYMKLVAQEYLQETLGQVVRSLCASTEDCEVDPSK---CPTPELPKCQARLRSSCEEVFENIIHS 595

  Fly  1020 HKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRN 1084
            :.:|||:|...|:.:||..:..|.:.:...|:.||:|||.||||||:||||.:..|.|:....|.
  Rat   596 YNYFPAELGTVFSNWREACKARGSEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPART 660

  Fly  1085 LTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYID 1149
            |||:||.:|.|||...|..||.:|.|:|.|||.....|:.||:.::.......|..   :.|..|
  Rat   661 LTLIAKVIQNLANCAPFGEKEAYMVFMNSFLEDHGPAMRHFLDQVAMVDTDTTPSG---YQGSGD 722

  Fly  1150 QGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTAL---------------- 1198
            ...||::||..|....|:|.:..:..|:||..||..|...:...:...:
  Rat   723 LALQLAVLHVQLCTIFAELDQKTRDSLEPLPTILQAIEEGRPVPVSVPMRLPLNTAHVQSSFSSG 787

  Fly  1199 --PGGYLPATSSTHS-IASENQENRNPGSSGSHAGSNSEQLLPQ---------QSQLA-QPQH-- 1248
              ||...|.....|: :.|::|..|:...:||.|....:...||         ||..| :|.|
  Rat   788 EKPGFLAPRDLPKHTPLISKSQSLRSFQGAGSWARRRPDGERPQRRPRPVLRTQSVPARRPTHHR 852

  Fly  1249 -AIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGH 1312
             |..|||  ..:|.:|               ..|..:|....:......::......:||.|.|.
  Rat   853 PAAGSKP--RPKGSLR---------------TGPATSGRAWARTSTSLPRKPSVPWQRQLDQPGD 900

  Fly  1313 Q-QQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHP 1376
            : |.|....|:..|:..|..:|         .|:..|...|....||:.....|....:|.....
  Rat   901 RYQTPGTHRPVGKLAEIQCEVA---------ALREEQKALSHLVESLSTHIQALTEQQEQLRCQL 956

  Fly  1377 QQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETS----------------TPSSTRSR 1425
            |.|.........:..:...:.....:....:.|...:.|.|                ||.| ||:
  Rat   957 QDLDSRLGAGISKLDSKGGLPSNGSLGLKSLEHRMTEMECSQNQLRDTLQSLQLLSKTPGS-RSQ 1020

  Fly  1426 TLPRNGNPNANG 1437
            ..|... |..||
  Rat  1021 PPPLKA-PCVNG 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	40/113 (35%)
		C2_SynGAP_like	721..874	CDD:175980	43/160 (27%)
		RasGAP_DAB2IP	865..1192	CDD:213338	120/327 (37%)
		DUF3498	<1927..1997	CDD:463427
Rasal3	NP_001401865.1	PH-like	200..346	CDD:473070	57/160 (36%)
		C2	319..451	CDD:472691	42/159 (26%)
		RasGAP_DAB2IP	443..766	CDD:213338	120/328 (37%)