DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and Rasal2

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_008767860.2	Gene:	Rasal2 / 304893	RGDID:	1307566	Length:	1289	Species:	Rattus norvegicus

Alignment Length:	1638	Identity:	430/1638 - (26%)
Similarity:	650/1638 - (39%)	Gaps:	530/1638 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 SNSLLKPNQAGILGSGSGSNGLGVHQGVMQGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDE 524
            |:|.|.|.....:...||:...|:...::   |...|      ...||.:.|    ||.......
  Rat    25 SDSPLPPEDLDAVVPVSGAVAGGMLDRIL---LESVC------QQQSWVRVF----DVKGPPTHR 76

  Fly   525 LNC----YFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETTATADDDAGHHSDTSY 585
            |:|    |.:....|:..|                 |..|..:...|:......|.....:|::.
  Rat    77 LSCGQSPYTETTSWERKYC-----------------ILTDSQLVLLNKEKEIPVDGQDQQADSTK 124

  Fly   586 EKACRR-------GSAPTTPILGS-----------------------KQHQTEHNATSRF--TNF 618
            .:..||       |..|..|..|:                       |.:..:...||.|  ..|
  Rat   125 GRCLRRTVSVPSEGQFPEYPPEGTAKLEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGF 189

  Fly   619 FSKK-SNPLKRTKSVTKLERT--------------KRGSGGLRGSRSHESLLSSHAVMSTIDLSC 668
            |||: ...:|||||.:||:|.              .||...|:.|||||||||..:.:..:||..
  Rat   190 FSKRLKGSIKRTKSQSKLDRNTSFRLPSLRNADDRSRGLPKLKESRSHESLLSPCSAVECLDLGR 254

  Fly   669 TGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSL 733
            ...|.|.|:|.|:||:..||:|. ...|.:.:||.|..|||.|:.:||:::.||.::.||.:|.|
  Rat   255 GEPVSVKPLHSSILGQDFCFEVT-YLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVL 318

  Fly   734 KMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVD 798
            ::|:.|||:|.|||:|||||.||.||:.||:.|.:.|.:||||||:|..:|.::.|||:::::|:
  Rat   319 RLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFYSLPPLHSITVHIYKDVE 383

  Fly   799 KKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIK 863
            ||||:||..:||.|.||...||.|...|:|||:.:..  .:.|:|.|            |::|||
  Rat   384 KKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPT--PNKGKTGG------------PSIRIK 434

  Fly   864 CRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDV 928
            .|||:..|||:..|..|..::..||..:|..|||||.|:.||::..|||.::.:.|.|..||||:
  Rat   435 SRFQTITILPMEQYKEFAEFITSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDL 499

  Fly   929 VALDLLRVGDQR-LTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSG 992
            |..::.|.|:.. |.||.|::||||:|.:|||.|:|||.|.|...|..|.:|:.:|||||:|.|.
  Rat   500 VMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSS 564

  Fly   993 SSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFL 1057
            |   .|...|:.||.....|:..|..|:..||.:|:..||:::::....|:||:::.|||||:||
  Rat   565 S---ELTDHQSNLRMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDLSERLISASLFL 626

  Fly  1058 RFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARM 1122
            |||||||:||||||:..|.|..|.:|.|||:||.:|.||||.:|..||.:|.|:|||||.|...|
  Rat   627 RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM 691

  Fly  1123 QQFLEIISTRPEHPAPDSILD---WAGYIDQGKQLSILHSLLSESLAKLP-------EARQHELD 1177
            ::||..||.      ||:|.:   :.||||.|::||:|||||.|.:::|.       :|...:|.
  Rat   692 KRFLLEISN------PDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLG 750

  Fly  1178 PLQHILDEIS--------------RAKEHGMGTALPGGYL---------PATSSTHSIASENQEN 1219
            ||..:|.:|:              |..||.....:.|...         |..|..|.:.|.:|:|
  Rat   751 PLPRVLADITKSLTNPTPIQQQLRRFAEHSSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDN 815

  Fly  1220 RNPGSSG------SHAGSNS---------EQLLP----------QQSQLAQPQHAIVSKPLSAER 1259
            .:....|      ..|.|.|         |..||          |.:..||.:|..|.  |....
  Rat   816 TDSYFRGKTLLLVQQASSQSMTYSEKDEKENSLPNGRSISLMDLQDTHTAQVEHGSVM--LDVPM 878

  Fly  1260 GIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQM 1324
            .:....|:...:         .::..|.:.|...|...|.::..|..|.|.|..|....|:|:..
  Rat   879 RLAGSQLSITQV---------ASIKQLRETQSTPQSAPQVRRPLHPALNQPGSLQPLSFQNPVYH 934

  Fly  1325 LSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQ 1389
            |:|.                                                       .|..|:
  Rat   935 LNNP-------------------------------------------------------VPAMPK 944

  Fly  1390 TSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMH 1454
            .||.|::|.:...:....| |..|::.|.||::......:..:       .|.:.::..:..|.|
  Rat   945 ASADSSLENLSTASSRSQS-NSEDFKLSGPSNSSMEDFTKRSS-------HSEDFSRRHTAPDRH 1001

  Fly  1455 GEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSH-HKLNLGIPDHSGGYVRGNNLNPNSNM 1518
            ....:                 |...|:      |:|. .||     |.||       |...:..
  Rat  1002 IPLAL-----------------PRQNST------GQSQIRKL-----DQSG-------LGARAKA 1031

  Fly  1519 PKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSIS 1583
            |.:|.                             |...|:                 |:|..|::
  Rat  1032 PPSLP-----------------------------HSASLR-----------------STGSMSVA 1050

  Fly  1584 TNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGS 1648
               |.:..:.||::      ||.:            :.|:.|||.|........|:||.||.
  Rat  1051 ---SAALVAEPVQN------GSRS------------RQQSSSSRESPVPKVRAIQRQQTQQV--- 1091

  Fly  1649 RLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSL 1713
             ..|:                  ::||::|                              .:|
  Rat  1092 -QSPV------------------DSATMSP------------------------------VER-- 1105

  Fly  1714 SGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQH 1778
                                   :|...||.....|||
  Rat  1106 -----------------------TAAWVLNNGQYEEDV--------------------------- 1120

  Fly  1779 PHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQL 1843
             .:.:||..:.:...:.:||               .|..:.||.:.|.|               |
  Rat  1121 -EETEQNQDEAKHAEKYEQE---------------ISKLKERLRVSSRR---------------L 1154

  Fly  1844 QEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELF 1908
            :|.:||..::            ||.:.|        .||:.            :|.|.||.:.|.
  Rat  1155 EEYERRLLVQ------------EQQMQK--------LLLEY------------KARLEDSEERLR 1187

  Fly  1909 GLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLITMEEELRREQLKMSLALSHKQRVIEEQ- 1972
            ..|.            :.:|.|:|||.       ||:.:||||:::..:|...:..||::|:.|
  Rat  1188 RQQE------------EKDSQMKSIIS-------RLMAVEEELKKDHAEMQAVIDAKQKIIDAQV 1233

  Fly  1973 --GQQIAALDAAN 1983
              |.:|.....|:
  Rat  1234 INGNEIVQTGKAD 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	50/130 (38%)
		PH	<656..720	CDD:278594	23/63 (37%)
		C2_SynGAP_like	721..874	CDD:175980	69/152 (45%)
		RasGAP	856..1185	CDD:214617	151/339 (45%)
		RasGAP_DAB2IP	865..1192	CDD:213338	149/351 (42%)
Rasal2	XP_008767860.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338159
Domainoid	1	1.000	123	1.000	Domainoid score	I5447
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1333
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm44855
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800