Protein Alignment raskol and Rasa3

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: NP_113762.1
• Gene: Rasa3 / 29372
• RGDID: 69365
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 776
• Identity: 171/776 - (22%)
• Similarity: 294/776 - (37%)
• Gaps: 187/776 - (24%)

  Fly   697 ERYYSCGSRQERDLWI--------------YSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKK 747
            :||::      ||.|.              ..|...::.....|....:.|...::|.:.||...
  Rat   103 QRYHN------RDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLAARIFECQGLPIVN 161

  Fly   748 RYFCELQLDKTLYG-------RTSVKLQT-----DLLFWGE-----------HFDFPDIPEINVI 789
            .. |:.....||.|       :|.||.:|     |.:|:.|           ||||.:
  Rat   162 GQ-CDPYATVTLAGPFRSEAKKTKVKKKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEE------- 218

  Fly   790 TVNVFREVDKKKKR-DKY---------QFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTS 844
                 .:|||.:.| |.:         :|:|.::||:|.:......|.|| .|..:
  Rat   219 -----EDVDKLEIRVDLWNASNLKFGDEFLGELRIPLHVLRYASSYEAWY-FLQPR--------- 268

  Fly   845 GGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKA------ 903
             ..||.|...:.|.:||:...:....:.....|......|.::     ..:|||....|
  Rat   269 -DNGSKSVKPDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKS-----ADVEPVSASAAHILGEV 327

  Fly   904 ---KEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYL 965
               |::....||.|:...|....|::.:.:.::.|..|....||||||.:|.::..:||.|..||
  Rat   328 CRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCIDETMKLAGMHYL 392

  Fly   966 QDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNC 1030
            ..||...|.|:.||.:.||:||.|.....  :|:....:||..|...:..|.:|....|..:.:.
  Rat   393 HVTLKPTIEEICQSHKSCEIDPVKLKDGE--NLENNMESLRQYVDRIFSVITKSGVSCPTVMCDI 455

  Fly  1031 FATFRERLQQLGRQDM--ADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQ 1093
            |.:.||...:..:.|:  ....:|:.|||||..||||||:||.:|......:.:|.|||::||:|
  Rat   456 FFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTIQ 520

  Fly  1094 TLANFTRFQG---KENFM----EFLNDFLEQEAARMQQFLEIIST---RPEHPAPDSILDWAGYI 1148
            ||.:.::.:.   ||::|    ||.|:  ::.|..::.||::||:   |........||...|::
  Rat   521 TLGSLSKSKSASFKESYMATFYEFFNE--QKYADAVKNFLDLISSSGRRDPKSIEQPILLKEGFM 583

  Fly  1149 ---DQGK------------------QLSILHSLLSESLAKLP-------EARQHELDPLQH---- 1181
               .||:                  :.:...|...:.|..:|       |..:.|...:::
  Rat   584 IKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENILAVERLEEESFRMKNMFQV 648

  Fly  1182 ----------------------ILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGS 1224
                                  ||.::|:..:..:....|..||.........:|:......|.:
  Rat   649 IQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGHWLCCRASSDTAIGCTPCT 713

  Fly  1225 SGSHAG--------SNSEQLLP----QQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFR 1277
            .|..|.        ..:|::..    ...:|.:.|.|..||      .:..|   |...|.:.|.
  Rat   714 GGLPANIQLDIDGDRETERIYSLFNLYMGKLEKMQEACGSK------SVYDG---PEQEEYSTFI 769

  Fly  1278 YNDP-----TVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIA 1333
            .:||     |:..::......:|:..|.::...:..::|.|:.|......|.....|:.|:
  Rat   770 IDDPQETYRTLKQVIAGVGTLEQEHAQYRRNKFKKTRYGSQEHPIGDKSFQNYIRQQSEIS 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	7/45 (16%)
		C2_SynGAP_like	721..874	CDD:175980	40/185 (22%)
		RasGAP_DAB2IP	865..1192	CDD:213338	97/401 (24%)
		DUF3498	<1927..1997	CDD:463427
Rasa3	NP_113762.1	C2A_RasA2_RasA3	13..133	CDD:176046	6/35 (17%)
		C2B_RasA3	146..288	CDD:175977	39/165 (24%)
		RasGAP_RASA3	297..565	CDD:213336	83/276 (30%)
		PH_GAP1_mammal-like	562..686	CDD:241522	15/123 (12%)
		BTK	679..714	CDD:128417	5/34 (15%)