DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and Rasa4

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_002727999.1	Gene:	Rasa4 / 288589	RGDID:	1565457	Length:	803	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	203/916 - (22%)
Similarity:	349/916 - (38%)	Gaps:	196/916 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 KIRDLAIHMASASAIGA-DLSVTTENETTATADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQ 606
            |...|:|.:.....:.| |::.:::.......|::....:.|.::..|        |..| :::|
  Rat     3 KRSSLSIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLC--------PFWG-EEYQ 58

  Fly   607 TEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGA 671
            .....|.....|:....:.|.|...:.|:..|:             ..|:||....   :..|..
  Rat    59 VHLPPTFHMVAFYVMDEDALSRDDVIGKVCLTR-------------DELTSHPKGF---IGWTHL 107

  Fly   672 VGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMW 736
            |.|.| ::.|.|..|                            ||..:.|....:|     |:..
  Rat   108 VEVDP-NEEVQGEIH----------------------------LRLEVVPGLHASR-----LRCS 138

  Fly   737 VYEAKNLPPKKRYFCELQLDKTLY-GR---TSVKLQTDLLFWGEHFDFP-DIPEINVITVNVFRE 796
            |.||::|.||.|........:..| ||   |||..::....|.|.|:|. :......:.|..: :
  Rat   139 VLEARDLAPKDRNGASDPFVRVHYNGRTQETSVVKKSCYPRWNETFEFELEKGATEALLVEAW-D 202

  Fly   797 VDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLR 861
            .|...:.|   |:|.|.:.|..:.|....|.|:.:..|::....|:    |..||        |:
  Rat   203 WDLVSRND---FLGKVVVNVQTLCSAQQEEGWFRLQPDQSKSRQGK----GNLGS--------LQ 252

  Fly   862 IKCRFQSTDILPINVYGNFLTYLKENYK-------RVCETLEPVIGVKAKEDIGQALVLLMHAQG 919
            ::.|.:...:||...|...:..|.:..|       ::...:|.....:.::::...|:.|...||
  Rat   253 LEVRLRDETVLPSVYYQPLVQLLCQEVKLGTQGPGQLIPVIEETTSAECRQEVATTLLKLFLGQG 317

  Fly   920 LAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCE 984
            ||...|..:..|:|.|..:....||.||||:||||:|||:.|.:||...|...|:.:.:.::..|
  Rat   318 LAKDLLDLLFQLELGRTSEANTLFRSNSLASKSMESFLKVAGMRYLHGILGPIIDRVFEEKKYVE 382

  Fly   985 VDPTKTSGSSAGS------------LQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATF--- 1034
            :||:|......|.            |::....||..:......|..|.:..||.:|   |||
  Rat   383 LDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLVALLSAICRSVRTCPAVVR---ATFRQL 444

  Fly  1035 ----RERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTL 1095
                |||......|::....:::.:.|||..||||||.||::......||.:|.|.|:||.:|.:
  Rat   445 FRRVRERFPSAQHQNVPFIAVTSFLCLRFFSPAILSPKLFHLRERHADARTSRTLLLLAKAVQNI 509

  Fly  1096 ANFTR--FQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYIDQGKQLSILH 1158
            .|...  .:.||::||.|...:.|...:::.|:            ..::|    |::.::|.:..
  Rat   510 GNMDTPVSRAKESWMEPLQPTVRQGVVQLKDFI------------TKLVD----IEEKEELDLQR 558

  Fly  1159 SLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMG--------------TALPGGYLPATSST 1209
            :|..::    |..::..|        .|.|.|  |.|              |.....:...:||.
  Rat   559 ALNLQA----PPVKEGPL--------FIHRTK--GKGPLASSSFKKLYFSLTTEALSFAKTSSSK 609

  Fly  1210 HSI--------ASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVL 1266
            .|:        |:|..|.::.|||.......|:.:  .::|....|...|:: |:.....:|.|:
  Rat   610 KSVFIKLASIRAAEKVEEKSFGSSHVMQVIYSDDV--GRAQTVYLQCKCVNE-LNQWLSALRKVI 671

  Fly  1267 TPN-----SLEKNIFR--------YNDPTVNGLLQQQQQQQQQQQQQQQQH----QQLQQH--GH 1312
            |.|     |....:||        ..:.|..|..:...:...|:......|    |.:.:|  |.
  Rat   672 TNNASLLGSYHPGVFRGDKWSCCHQKEKTDLGCDKTHSRVTLQEWNDPLDHDLEAQLIYRHLLGV 736

  Fly  1313 QQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQ 1377
            :.....:|  |:||.: |..||.......|..:.:.:|.......|..:.|:.|      |..|.
  Rat   737 EAALREKH--QLLSRA-TEEAGTSSTGRGGAPEDSLAQLLRVLRDLREAHSSSL------ASSPS 792

  Fly  1378 QLHPHH 1383
            : .|.|
  Rat   793 R-EPRH 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	19/113 (17%)
		PH	<656..720	CDD:278594	11/63 (17%)
		C2_SynGAP_like	721..874	CDD:175980	38/157 (24%)
		RasGAP	856..1185	CDD:214617	89/356 (25%)
		RasGAP_DAB2IP	865..1192	CDD:213338	91/354 (26%)
Rasa4	XP_002727999.1	C2A_Rasal1_RasA4	6..126	CDD:176018	28/173 (16%)
		C2	134..256	CDD:301316	35/142 (25%)
		RasGAP	245..604	CDD:214617	98/403 (24%)
		RasGAP	264..549	CDD:295371	81/303 (27%)
		PH_CAPRI	541..680	CDD:241523	31/171 (18%)
		PH	566..671	CDD:278594	22/117 (19%)
		BTK	680..708	CDD:279161	5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840