DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and gap-3

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_490916.5	Gene:	gap-3 / 260016	WormBaseID:	WBGene00021238	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	1083	Identity:	202/1083 - (18%)
Similarity:	334/1083 - (30%)	Gaps:	369/1083 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 STSNTTTTTTTTTLITLRAKSKTLPQNLSPSVVLREAAALDELEKKREKYQEKQEKREKLQEKQR 376
            |:.|||..::|...:.|:..:...|.::||:.|....    ||.:               .:...
Worm     3 SSENTTPNSSTEGPLFLKTHTNPTPPDISPNDVWYHG----ELNE---------------HDANH 48

  Fly   377 QLFGGSTASQI---AGSSPYKLQNSCSATSILTHSFPPKNLFLLKSTP--------KLST--DIA 428
            .|.|.|..:.:   .|.:.:.|       |||.....||:|.:.:.||        :..|  ||.
Worm    49 LLQGTSPGAFLVRQTGQTRFYL-------SILDQDGYPKHLPIRQLTPPHYFFEGKRFETLRDIV 106

  Fly   429 AA-------------TPPN-----TSAICSPPKKSLSFIRRAHSTKVARSN-------SLLKPNQ 468
            .|             .|.|     |..:|         :||....::...|       |:.:.::
Worm   107 DAYQLAVIPVRKGGIMPINGEIQETKYLC---------VRRFEQREIDEMNSEIGDILSVCETDE 162

  Fly   469 AG-ILGSGSGSNGLGVHQGVMQGALS--ISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELNCYF- 529
            .| :||....|..:|:   :::..|.  |:...|.|..     .:||.......:....:..:.
Worm   163 TGWMLGRNETSGSVGI---ILRSHLEPLITEVADLSDL-----PYFYDTVSTDMVQYSPIGTFLL 219

  Fly   530 ----------------QADQCEKLICERFKIRDLAIHMASASAIG------ADLSVTTENETTAT 572
                            |.|..||.:......|..::.......||      .|.:::.....|
Worm   220 RRSSKGTDTYALLVKTQFDLVEKFLIVGCPSRGFSLAGRPFPTIGHVLTRYCDRAISGGVRLT-- 282

  Fly   573 ADDDAGHHSDTSYEK--ACRRGSAPT--TPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVT 633
                  |.....:::  :.||.:|..  .|.:|   ::|...::|::.:...::
Worm   283 ------HAVCVKHQRKSSSRRSTAEVRWPPFIG---NETASMSSSQYDDGLREQ----------- 327

  Fly   634 KLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGER 698
            |..|..||:.......|..|.|:|...|.:  .|.|.:.|: |.|  ::.|.|...|...|
Worm   328 KPRRMFRGTSIDTALASSSSFLTSSTAMPS--PSTTVSTGI-PEH--LIDRFHDEDVNNHP---- 383

  Fly   699 YYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYG-- 761
              ...|.........:||||            ...|.|         |:   |.|.|.....|
Worm   384 --ETSSSTTTVAATVALRKS------------REEKQW---------KE---CWLTLSDIPGGSS 422

  Fly   762 ------------RTSVKLQTDLLFW---------GEHFDFPDIPEINVITVNV-FRE-------V 797
                        |..|.|.|..|||         |..|..|..|:....|:.: ||.       :
Worm   423 QLSVFDSMGSKLRQQVDLSTCTLFWLDESVFCADGCLFLSPSFPQQQPPTLYLCFRPYTAFLKWI 487

  Fly   798 DKKKKRDKYQFV------GSVKI--PVHDV-----------TSRLPCEQWYPILSDKAGDSLGRT 843
            ...:.|..||.|      |::.:  |...|           :..|..:.:|.......|..:|.:
Worm   488 RILRSRTIYQDVPPPMLQGTISVGEPNSQVSILSIEIDKFRSELLKSDMFYSAQVSLNGVKIGVS 552

  Fly   844 SGGGGSGSKDKEQLPTLRIKCRFQ-------STDI-LPINVYGNF-----------LTYLKENYK 889
            :....:|:|...::|.:.|..:|.       ||:| |.:|.:.:.           ...|.||.:
Worm   553 NAFAPAGNKGPNEMPVVVIDSKFVIPCIPTCSTNIQLSMNSHSSIGKRGRPCGVTVTICLNENNE 617

  Fly   890 RVCETLEPVIGVKAKEDIGQALVL--------------------------------------LMH 916
            .:|::.....|...:....:..||                                      :.|
Worm   618 SICQSQADSTGFVFRAQRNRCPVLPLDRYKPLLDMIRECPSSILSWPSQVLPSHLKQFMYTCISH 682

  Fly   917 AQGLAGAFLTDVVAL---DLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELI- 977
            ...|...|::.|:..   |:|........||.:||||..:        .|.|:.....|.:|.:
Worm   683 LYALNPQFMSQVIRRIINDILVTSTAEDVFRKDSLATGII--------TQCLRHLFKTPFDEFLL 739

  Fly   978 ------QSERDCEVDPTKTSGSSAGSL------QR--------QQAALRGAVRGAWQCIFESHKH 1022
                  ||.:...:|    ||..|..|      ||        :...:.....|   |.|...:|
Worm   740 ENAQFSQSLKQQNLD----SGGGAVELLVNFVDQRLLTIPLATRLLTIAAECAG---CRFGDEQH 797

  Fly  1023 FPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTL 1087
                                .|.:....:||.:.||.|.|.|.|.....|.|:
Worm   798 --------------------EQHLIKRTLSALLILRVLNPIIFSTLNTGIGSQ------------ 830

  Fly  1088 VAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEII-----STRPEHPAPDSIL----- 1142
            :||.:|..||....|..       .|.|...|:.:::..:.|     ..:|.....||.:
Worm   831 IAKLVQISANSAASQTP-------TDSLTPAASTIRRMFDRIIFLVNQQQPAESPEDSEIGEVHT 888

  Fly  1143 DWAGYIDQ--GKQLSILHSLLSESL-AKLPEARQHELDPLQHI 1182
            :|...:..  |..|:|..:..||.: ..||..   ||..|.|:
Worm   889 EWISCLTYMIGHSLTIRSATSSEDVHLPLPVL---ELIRLHHL 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	23/113 (20%)
		PH	<656..720	CDD:278594	16/63 (25%)
		C2_SynGAP_like	721..874	CDD:175980	41/210 (20%)
		RasGAP	856..1185	CDD:214617	80/421 (19%)
		RasGAP_DAB2IP	865..1192	CDD:213338	78/412 (19%)
gap-3	NP_490916.5	SH2	36..109	CDD:198173	18/98 (18%)
		SH3	139..186	CDD:302595	8/49 (16%)
		SH2	198..270	CDD:198173	9/71 (13%)
		PH-like	398..491	CDD:302622	25/116 (22%)
		RasGAP	646..865	CDD:213328	49/272 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810