DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and Syngap1

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_006524298.1	Gene:	Syngap1 / 240057	MGIID:	3039785	Length:	1407	Species:	Mus musculus

Alignment Length:	1583	Identity:	427/1583 - (26%)
Similarity:	656/1583 - (41%)	Gaps:	442/1583 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 KHFYQPYD-------VCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTE 566
            ::.:.|||       .|.:|.::| .....|:...|:     |||.....:....:...:||..|
Mouse    33 QYVHSPYDRPGWNPRFCIISGNQL-LMLDEDEIHPLL-----IRDRRSESSRNKLLRRTVSVPVE 91

  Fly   567 NETTATADDDAGHHSDTSYEKA-CRRGSAPTTPILGSKQHQTEHNATSRF---TNFFSKK-SNPL 626
            ...          |.:..|... .||.|.|     |.||:..|....:.|   ..|.|:: .:.:
Mouse    92 GRP----------HGEHEYHLGRSRRKSVP-----GGKQYSMEAAPAAPFRPSQGFLSRRLKSSI 141

  Fly   627 KRTKSVTKLERTK-----------------RGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGV 674
            |||||..||:||.                 |.....:.|.|||||||..:....::|:......:
Mouse   142 KRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSII 206

  Fly   675 APVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYE 739
            .|||.|:||:..||:|... .|.:.::|.|..|||.||.:|::::.||.:::||.||.||:|:.|
Mouse   207 KPVHSSILGQEFCFEVTTS-SGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIE 270

  Fly   740 AKNLPPKKRYFCELQLDKTLYGRTSVKLQT---DLLFWGEHFDFPDIPEINVITVNVFREVDKKK 801
            |:.|||||||:|||.||..||.||:.|.::   |.:||||||:|.::|.:..:.::::|:.|||:
Mouse   271 ARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKR 335

  Fly   802 KRDKYQFVGSVKIPVHDVTSRLPCEQWYPI-LSDKAGDSLGRTSG-----GGGSGSKDKEQLPTL 860
            |:||..:||.|.:||..:..|...|||||: |...:|.|.|..||     |||||.|.|...|.:
Mouse   336 KKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAV 400

  Fly   861 RIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFL 925
            |:|.|:|:..|||:.:|..|..|:..:|:.:|..|||.:.||.||::..|||.::.:.|.|..||
Mouse   401 RLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFL 465

  Fly   926 TDVVALDLLRVGD-QRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTK 989
            :|:...::.|..: :.|.||.|:||||::|.:::|.|::||:|.:...|..|.:||.:|||||.|
Mouse   466 SDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK 530

  Fly   990 TSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISAS 1054
               .:|.||...||.||.....|...:..||..||.:|:..||::|.|..:.||:|:||.|||||
Mouse   531 ---CTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISAS 592

  Fly  1055 IFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEA 1119
            :|||||||||:|||||.:..|.|..:.:|.|||:||.:|.||||::|..||:|:.|:|:|||.|.
Mouse   593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEW 657

  Fly  1120 ARMQQFLEIISTRPEHPAPDSILD---WAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQH 1181
            ..|||||..||..      |::.:   :.||||.|::||.||:||.|.|.:|.:....:|.||..
Mouse   658 GSMQQFLYEISNL------DTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPR 716

  Fly  1182 ILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQP 1246
            :|::||        |||                     |||
Mouse   717 LLNDIS--------TAL---------------------RNP------------------------ 728

  Fly  1247 QHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHG 1311
                                       ||              |:|..:|.::.:.|...|:...
Mouse   729 ---------------------------NI--------------QRQPSRQSERTRSQPMVLRGPS 752

  Fly  1312 HQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHP 1376
            .:.|.:      |:.:..:||....:|:.  ||..:.....:.|.:
Mouse   753 AEMQGY------MMRDLNSSIDLQSFMAR--GLNSSMDMARLPSPT------------------- 790

  Fly  1377 QQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGS 1441
                 ...||.|.......:..:.|   |.::.:...|.||:...|.    |.....:.|.:|
Mouse   791 -----KEKPPPPPPGGGKDLFYVSR---PPLARSSPAYCTSSSDITE----PEQKMLSVNKSV-- 841

  Fly  1442 SNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGY 1506
                   |..|:.|:                           ||.|
Mouse   842 -------SMLDLQGD---------------------------GPGG------------------- 853

  Fly  1507 VRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAK 1571
                  ..||:...||..:.||.               :.:|........|:||.. |:....:.
Mouse   854 ------RLNSSSVSNLAAVGDLL---------------HSSQASLTAALGLRPAPA-GRLSQGSG 896

  Fly  1572 SSHCSSGYQ----SISTNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQ-----PQTGSSR 1627
            ||..::|.:    .::|:..|:|       ||:       .||:|:||.:.:.     |..|...
Mouse   897 SSITAAGMRLSQMGVTTDGVPAQ-------QLR-------IPLSFQNPLFHMAADGPGPPAGHGG 947

  Fly  1628 S------SAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAAT----------- 1675
            |      |:..:.|.....:..:..|....|..|   .:::..|:||.....|.
Mouse   948 SSGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHG---YSKSEDLSSGVPKPPAASILHSHSYSDE 1009

  Fly  1676 LTPSSSD---EQLSADNYFSY---------------------AAAAAAGAGIATKLEAQRSLSGG 1716
            ..||.:|   .|||..:...:                     .:...:|.|....|:..:|....
Mouse  1010 FGPSGTDFTRRQLSLQDSLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGQPPPLQRGKSQQLT 1074

  Fly  1717 SSSSTSASASTSNLGKSGGSSAYGRL---NGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQH 1778
            .|::.....|:.||.:|...| ||..   ...|.:|...| |.|||.|..|.||..|....|.|.
Mouse  1075 VSAAQKPRPSSGNLLQSPEPS-YGPARPRQQSLSKEGSIG-GSGGSGGGGGGGLKPSITKQHSQT 1137

  Fly  1779 PHQQQQNPMQQQQQR--------------------ERDQ-EHKQYAGSVAGSVGSATSAAQRRLS 1822
            |  ...||.....:|                    ||:: :.|:|:                 .|
Mouse  1138 P--STLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYS-----------------KS 1183

  Fly  1823 LDSARTLSDSSTDTEGHCNQLQE--GKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQT 1885
            :|.:|.  |...:.|...:.|:|  ....|:|..          .|:.|....:|..:|.:..|.
Mouse  1184 MDESRL--DRVKEYEEEIHSLKERLHMSNRKLEE----------YERRLLSQEEQTSKILMQYQA 1236

  Fly  1886 LDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLITMEEE 1950
                  .|::.|..||..                   .::.:|.::|||.       ||:.:|||
Mouse  1237 ------RLEQSEKRLRQQ-------------------QVEKDSQIKSIIG-------RLMLVEEE 1269

  Fly  1951 LRREQLKMSLALSH-KQRVIEEQ 1972
            |||:...|:..|.. |:|:::.|
Mouse  1270 LRRDHPAMAEPLPEPKKRLLDAQ 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	43/134 (32%)
		PH	<656..720	CDD:278594	20/63 (32%)
		C2_SynGAP_like	721..874	CDD:175980	75/161 (47%)
		RasGAP	856..1185	CDD:214617	143/332 (43%)
		RasGAP_DAB2IP	865..1192	CDD:213338	142/330 (43%)
Syngap1	XP_006524298.1	PH_SynGAP	122..313	CDD:270178	74/191 (39%)
		C2_SynGAP_like	252..414	CDD:175980	75/161 (47%)
		RasGAP_DAB2IP	405..728	CDD:213338	146/360 (41%)
		DUF3498	718..1292	CDD:371844	152/865 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834586
Domainoid	1	1.000	123	1.000	Domainoid score	I5556
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm42791
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.830