Protein Alignment raskol and RASA3

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_047286110.1
• Gene: RASA3 / 22821
• HGNCID: 20331
• Length: 878
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 190/840 - (22%)
• Similarity: 311/840 - (37%)
• Gaps: 232/840 - (27%)

  Fly   676 PVHQSVLGRR---HCFQVRGGPRGERYYSCGSRQERDLWIY----------SLRKSIAPNAE--- 724
            |:..|..|||   ...|..|...||.:|....|..|.|..|          |:...:|...|
Human    83 PLPGSAQGRRTLSPAAQALGPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQ 147

  Fly   725 --HTRRT---------DNSLKMWVY------------------------EAKNLPPKKRYFCELQ 754
              |.|.|         |:.::..|:                        |.:.||..... |:..
Human   148 KYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPY 211

  Fly   755 LDKTLYG-------RTSVKLQT-----DLLFWGE-----------HFDFPDIPEINVITVNVFRE 796
            ...||.|       :|.||.:|     |.:|:.|           ||||.:            .:
Human   212 ATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEE------------ED 264

  Fly   797 VDKKKKR-DKY---------QFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGS 851
            |||.:.| |.:         :|:|.::||:..:......|.|| .|..:          ..||.|
Human   265 VDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWY-FLQPR----------DNGSKS 318

  Fly   852 KDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKA---------KEDI 907
            ...:.|.:||:...:....:...:.|......|.::     ..:|||....|         |::.
Human   319 LKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKS-----ADVEPVSASAAHILGEVCREKQEA 378

  Fly   908 GQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAP 972
            ...||.|....|....|::.:.:.::.|..|....|||||||:|.::..:||.|..||..||...
Human   379 AVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPA 443

  Fly   973 INELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRE- 1036
            |.|:.||.:.||:||.|.....  :|:.....||..|...:..|.||....|..:.:.|.:.||
Human   444 IEEICQSHKPCEIDPVKLKDGE--NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREA 506

  Fly  1037 ---RLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANF 1098
               |.|.  ..|:....:|:.|||||..||||||:||.:|......:.:|.|||::||:|||.:.
Human   507 AAKRFQD--DPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSL 569

  Fly  1099 TRFQG---KENFM----EFLNDFLEQEAARMQQFLEIIST---RPEHPAPDSILDWAGYI---DQ 1150
            ::.:.   ||::|    ||.|:  ::.|..::.||::||:   |........|:...|::   .|
Human   570 SKSKSASFKESYMATFYEFFNE--QKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQ 632

  Fly  1151 GKQL--------------------------SILHSLLSESLAKLPEARQHE---------LDPLQ 1180
            |::.                          ..|:|:..|::..:.:..:..         :.|.:
Human   633 GRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 697

  Fly  1181 ----------------HILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHA 1229
                            .||.::|:..:..:....|..||    |.|.:......:..||.|....
Human   698 ALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYL----SGHWLCCRAPSDSAPGCSPCTG 758

  Fly  1230 G------------SNSEQLLP----QQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRY 1278
            |            ..:|::..    ..|:|.:.|.|..||      .:..|   |...|.:.|..
Human   759 GLPANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSK------SVYDG---PEQEEYSTFVI 814

  Fly  1279 NDP-----TVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQ--MLSNSQTS 1331
            :||     |:..::......:|:..|.::...:..::|.|:.|......|  :...|:||
Human   815 DDPQETYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETS 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	19/70 (27%)
		C2_SynGAP_like	721..874	CDD:175980	43/223 (19%)
		RasGAP_DAB2IP	865..1192	CDD:213338	99/403 (25%)
		DUF3498	<1927..1997	CDD:463427
RASA3	XP_047286110.1	C2	<99..177	CDD:472691	17/77 (22%)
		C2B_RasA3	190..332	CDD:175977	37/165 (22%)
		RasGAP_RASA3	341..609	CDD:213336	87/278 (31%)
		PH_GAP1_mammal-like	606..730	CDD:241522	13/123 (11%)
		BTK	723..758	CDD:128417	8/38 (21%)